Synovial Cytokine Modulation Following Perinatal Tissue Therapy in Equine Joints ± NSAID Administration

Synovial Cytokine Modulation Following Perinatal Tissue Therapy in Equine Joints ± NSAID Administration | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 5 March 2026 V1 Latest version Share on Synovial Cytokine Modulation Following Perinatal Tissue Therapy in Equine Joints ± NSAID Administration Authors : C. Loughran [email protected] , Fairfield Bain , E. McNeil , M Perez , Jon Drobnis , A. Smith , and M DiPaola 0000-0003-3491-7565 Authors Info & Affiliations https://doi.org/10.22541/au.177273566.69575148/v1 155 views 55 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Osteoarthritis (OA) is a leading cause of lameness in horses. A number of treatment modalities are currently available for OA, including NSAIDs, disease modifying systemic drugs such as pentosan polysulfate (PPS), corticosteroids, platelet rich plasma (PRP), autologous conditioned serum (IRAP/ACS), stem cell therapy (MSC), extracellular vesicles (EVs) and amnion products. While NSAIDs and steroids alleviate pain and inflammation temporarily, they have minimal impact on stopping or reversing joint damage. Therapeutics modalities such as PRP, IRAP, MSC, EVs and amnion products are more likely to not only block inflammation but also potentially reverse joint damage. Over the past decade, the use of regenerative therapeutics in veterinary medicine has garnered significant interest. While stem cells represent a familiar approach to induce tissue regeneration and healing 1 , other therapeutic products such as tissue-derived biologics, as well as purified biologics from natural tissues have shown great promise in the treatment of various diseases and musculoskeletal system injuries 2 . Supplementary Material File (modulation_of_cytokines_and_growth_factors_in_-_fv_250226_na_formatted.docx) Download 5.06 MB Information & Authors Information Version history V1 Version 1 05 March 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations C. Loughran [email protected] Peterson Smith Equine Hospital View all articles by this author Fairfield Bain Rood And Riddle Equine Hospital View all articles by this author E. McNeil Ovid Technologies Inc Norwood View all articles by this author M Perez Peterson Smith Equine Hospital View all articles by this author Jon Drobnis Ovid Technologies Inc Norwood View all articles by this author A. Smith Peterson Smith Equine Hospital View all articles by this author M DiPaola 0000-0003-3491-7565 Ovid Technologies Inc Norwood View all articles by this author Metrics & Citations Metrics Article Usage 155 views 55 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation C. Loughran, Fairfield Bain, E. McNeil, et al. Synovial Cytokine Modulation Following Perinatal Tissue Therapy in Equine Joints ± NSAID Administration. Authorea . 05 March 2026. 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