Clinical effects of Levonorgestrel-Releasing Intrauterine System in 98 women

Objective To evaluate the safety and efficacy of levonorgestrel-releasing intrauterine system(LNG-IUS) for the women who are suffered from endometriosis(EM),dysfunctional uterine bleeding(DUB) or simply intended to contraception. Methods Ninety-eight cases of EM,DUB or simply intending contraception were enrolled from the Department of Family Planning Clinics. The primary endpoints were defined as controlling menstruation, side effects and satisfaction after placing LNG-IUS for 3, 6 and 12 months. Meanwhile, the visual analogue scale(VAS) score was used to assess the degree of dysmenorrhea. Results For the 34 DUB patients, their menstrual quantity after placing LNGIUS for 3,6 and 12 months decreased significantly compared with the levels of their baseline(P0.001). The VAS scores of the 47 EM patients of the baseline levels were significantly different from those of the follow-up levels(P 0.001).Overall, no woman was pregnant in cases of intended to contraception. And 59 women(64.9%, 59 / 91) were very satisfied or satisfied with the one-year treatment. Conclusion LNG-IUS is a safe and efficient method for the therapy of EM and DUB, as well as for birth control.