[The dinitrosyl-iron complexes with cysteine block the development of experimental endometriosis in rats].

Burgova En, E N Burgova, N A Tkachev, Tkachev Na, A F Vanin, Vanin Af
Biofizika · 2012 · vol. 57(1) , pp. 105–9 · PMID:22567916 · W2406765218
article OA: closed CC0 ⤵ 1 in-corpus citation
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Abstract

It has been shown that the administration of 0,5 ml of 5 mM aqueous solution of dinitrosyl-iron complexes (DNIC) with cysteine alleviated the development of experimental endometriosis in rats induced by surgical way: the size of endometriomes decreased 1.85 times when the DNIC was added every day during 10 days. The effect was suggested to be due to cytotoxic action of NO molecules and nitrosonium ions (NO+) released from rapidly decomposed DNIC in animal organism on endometriome tissues.

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Condition tags

endometriosis

MeSH descriptors

Cysteine Endometriosis Iron Nitrogen Oxides Animals Cysteine Cysteine Cysts Cysts Cysts Cysts Disease Models, Animal Electron Spin Resonance Spectroscopy Endometriosis Endometriosis Endometriosis Female Injections, Intraperitoneal Iron Iron

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