Distribution of interleukin-6 promoter region and AHSG gene polymorphism in patients with endometriosis

Objective:To detect the distribution of polymorphism at Sac I site G/C in the seventh extron of AHSG gene and IL-6 promoter region -572 C\G in patients with endometriosis and normal controls.Methods:Interleukin-6 gene promoter region and Sac I site in the seventh extron of AHSG gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in patients with endometriosis (n=98) and normal controls (n=99).Results:To IL-6 promoter region -572, the frequencies of CC,CG and GG genotypes were 55.10%,42.86% and 2.04% in patients with endometriosis, while 70.71%, 28.28% and 1.01% in normal controls. A significant difference was seen in the distribution frequency in two groups; To Sac I site G/C in the seventh extron of AHSG gene, the frequencies of GG, GC and CC genotypes were 32.65%, 57.14% and 10.20% in patients with endometriosis, while 74.75%, 23.23% and 2.02% in normal controls. A significant difference was seen in the distribution frequency in the two groups.Conclusion:The distribution frequency of interleukin-6 genotype and AHSG gene have something to do with morbility of endometriosis; Genotypes C/C in IL-6 gene and G/G in AHSG gene may have a protective effect against endometriosis; There may exist some interaction between polymorphisms of IL-6 gene and AHSG gene in the pathogenesis of endometriosis.