MÜLLERIAN INHIBITING SUBSTANCE (MIS) ANALOGUES
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Mullerian Inhibiting Substance analogues featuring non-natural glycosylation, protease cleavage sites, or tags are disclosed for treating endometriosis and other conditions linked to uncontrolled Mullerian duct-derived tissue growth.
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Abstract
Mullerian Inhibiting Substance analogues are disclosed which comprise one or more non-naturally occurring N-linked glycosylation sites, protease cleavage sites, and/or tags such as an epitope tag. Also disclosed are pharmaceutical compositions comprising such compositions and methods of using such compositions, for example in the treatment of conditions associated with uncontrolled growth of a tissue derived from a Mullerian duct, such as the condition endometriosis.
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- europepmc
- last seen: 2026-08-17T06:11:01.428247+00:00