Endometrial polyps affect uterine receptivity.

Rackow BW, Elisa M. Jorgensen, Jorgensen E, Hugh S. Taylor
Fertility and sterility · 2011 · doi:10.1016/j.fertnstert.2010.12.034 · PMID:21269620 · PMC3096716
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This case-control study found that endometrial polyps significantly decrease HOXA10 and HOXA11 mRNA levels, providing a molecular mechanism for impaired uterine receptivity and reduced implantation rates.

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Abstract

This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair implantation. These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps.

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europepmc
last seen: 2026-09-27T09:11:36.575535+00:00