More than menorrhagia: A review of the obstetric and gynaecological manifestations of von Willebrand disease

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This review examines the various obstetric and gynecological conditions associated with von Willebrand disease beyond heavy menstrual bleeding.

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Abstract

Menorrhagia is the most common symptom experienced by women with von Willebrand's disease (VWD), but several other gynaecological disorders also occur more frequently in these women; primarily ovarian cysts and endometriosis. Women with VWD are most likely to experience an increased incidence of gynaecological disorders and obstetric complications that manifest with bleeding. The incidence of these disorders and the complications of pregnancy are discussed with particular reference to a case-control study conducted by the U.S. Centers for Disease Control and Prevention.

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MeSH descriptors

Menorrhagia Pregnancy Complications, Hematologic von Willebrand Diseases Female Humans Menorrhagia Menorrhagia Pregnancy Pregnancy Complications, Hematologic Pregnancy Complications, Hematologic von Willebrand Diseases von Willebrand Diseases

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europepmc
last seen: 2026-08-12T06:07:16.479679+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:15:00.519696+00:00
License: CC0 · commercial use OK