Retinoid and bone metabolic marker in ossification of the posterior longitudinal ligament

Tomoko Kodama, T Kodama, S. Matsunaga, E Taketomi, Eiji Taketomi, Takashi Sakou, T Sakou
In vivo (Athens, Greece) · 1998 · vol. 12(3) , pp. 339–44 · PMID:9706481 · W21615735
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Serum retinol and retinol binding protein levels were elevated in patients with cervical ossification of the posterior longitudinal ligament, particularly those with diffuse idiopathic skeletal hyperostosis, while bone metabolic markers remained normal.

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Abstract

The pathogenesis of ossification of the posterior longitudinal ligament (OPLL) remains to be elucidated, though etiologic factors for OPLL have been identified. High levels of serum retinol and retinol binding protein (RBP) have been observed in patients with diffuse idiopathic skeletal hyperostosis (DISH). OPLL is often associated with DISH. In this study, the levels of serum retinol and RBP were determined in 70 patients with OPLL in the cervical spine, and compared with those in normal subjects. Bone metabolic markers of serum intact osteocalcin, urinary pyridinoline and deoxypyridinoline were examined as well. Among female patients, level of serum RBP was significantly higher in those in their 60's, and those with mixed type OPLL. Level of serum RBP was significantly higher in both sexes, and retinol was exhibited higher in female patients, if they were associated with DISH. Patients with OPLL exhibited no abnormal bone metabolic marker levels. These findings suggest that vitamin A may play a role in the development of OPLL.

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MeSH descriptors

Bone and Bones Hyperostosis, Diffuse Idiopathic Skeletal Ossification of Posterior Longitudinal Ligament Vitamin A Adult Amino Acids Amino Acids Amino Acids Bone and Bones Female Humans Hyperostosis, Diffuse Idiopathic Skeletal Hyperostosis, Diffuse Idiopathic Skeletal Longitudinal Ligaments Longitudinal Ligaments Male Middle Aged Ossification of Posterior Longitudinal Ligament Ossification of Posterior Longitudinal Ligament Osteocalcin

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