A Bayesian mesh meta-analysis of medicine treatment in patients with enuresis

Background: The aim of this study was to comprehensively evaluate the efficacy of multiple methods for enuresis and chose optimal treatment plan. Methods We searched Pubmed, Embase and Cochrane Library for included articles. All data were analyzed comprehensively using aggregate data drug information system (ADDIS) software (1.16.5). The random effects model was used for all test models. Node-splitting analysis and inconsistency standard deviation (ISD) were applied for consistency test. For node-splitting analysis (NSA) with Pb > 0.05, consistency model was chosen for analysis. Otherwise, the inconsistency model was used. Results Twenty-one studies were included in this meta-analysis. For the response rates, desmopressin acetate tablets (dDAVP) + Tolterodine (Tol), dDAVP + Imipramine (Imi), Imi + oxybutynin (Oxy), and Imi + Pseudoephedrine (Pse) treatment were the best, while the efficacy of Verapamil (Ver), Mianserin (Mia) and Estradiol (Est) were the worst. For the mean number of nocturia indicator, the effects of dDAVP + Imi and dDAVP + Tamsulosin (Tam) treatment were the best, while the efficacy of Imi was the worst. For nocturnal urine volume, the effects of dDAVP + Oxy and dDAVP + Tam were the best, while the efficacy of Pse and Tam were the worst. However, the difference between the groups was not statistically significant (P > 0.05). For adverse effects index, the incidence of adverse effects of Est and dDAVP + Imi was the lowest, the incidence of Ver was the highest. Conclusions The effects of dDAVP + Imi and dDAVP + Tam were the best, while Ver was with the worst efficacy.