Thrombin activatable fibrinolysis inhibitor as an indicator of the severity of acute pancreatitis.

Radovanović-Dinić B, Tešić-Rajković S, Ignjatovic A, Grgov S
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018 · doi:10.5152/tjg.2018.17666 · PMID:30249565 · PMC6284639
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This prospective study evaluated the utility of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) levels in assessing the severity of acute pancreatitis among 92 patients. Researchers categorized participants into mild, moderate, and severe groups according to the revised Atlanta classification and analyzed various biochemical and inflammatory markers. The results indicated that TAFI concentrations were significantly higher in patients with complicated forms of the disease compared to those with mild cases. Furthermore, TAFI demonstrated superior discriminatory ability for identifying severe acute pancreatitis when compared to other inflammatory biomarkers like C-reactive protein and fibronectin. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background/aimsThrombin Activatable Fibrinolysis Inhibitor (TAFI), in addition to suppressing fibrinolysis, can be involved as a natural anti-inflammatory molecule in the inflammatory process in acute pancreatitis (AP). The goal of this study was to discover the significance of early determination of the values of TAFI in the assessment of the severity of AP.Materials and methodsThe prospective study included 92 patients with AP. In accordance with the revised Atlanta classification, we divided all patients into 3 groups (I-mild AP, II- moderate AP and III-severe AP). All patients were further classified into group A (mild AP) and group B (moderate and severe AP) with the aim of separating the patients with complicated and potentially bad prognosis. Biochemical markers, inflammatory biomarkers, coagulation parameters and TAFI were analyzed in all patients.ResultsThe level of TAFI were significantly higher among the patients with the complicated form (group B) of AP (p=0.002). The analysis of the ROC curve in regard to the inflammatory biomarkers (fibronectin and CRP) has shown that TAFI possesses the best discriminatory ability for complicated forms of AP (AUC=0.724, p=0.013), with the sensitivity of 83.30% and the specificity of 56.00%.ConclusionThe level of TAFI in plasma is higher in patients with moderate or severe AP. Determining the level of TAFI as a single parameter has a greater significance in the early estimation of the severity of AP than inflammatory biomarkers that we have analyzed.
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Full Text Full Text PDF Abstract Abstract Background/Aims: Thrombin Activatable Fibrinolysis Inhibitor (TAFI), in addition to suppressing fibrinolysis, can be involved as a natural anti-inflammatory molecule in the inflammatory process in acute pancreatitis (AP). The goal of this study was to discover the significance of early determination of the values of TAFI in the assessment of the severity of AP. Materials and Methods: The prospective study included 92 patients with AP. In accordance with the revised Atlanta classification, we divided all patients into 3 groups (I-mild AP, II- moderate AP and III-severe AP). All patients were further classified into group A (mild AP) and group B (moderate and severe AP) with the aim of separating the patients with complicated and potentially bad prognosis. Biochemical markers, inflammatory biomarkers, coagulation parameters and TAFI were analyzed in all patients. Results: The level of TAFI were significantly higher among the patients with the complicated form (group B) of AP (p=0.002). The analysis of the ROC curve in regard to the inflammatory biomarkers (fibronectin and CRP) has shown that TAFI possesses the best discriminatory ability for complicated forms of AP (AUC=0.724, p=0.013), with the sensitivity of 83.30% and the specificity of 56.00%. Conclusion: The level of TAFI in plasma is higher in patients with moderate or severe AP. Determining the level of TAFI as a single parameter has a greater significance in the early estimation of the severity of AP than inflammatory biomarkers that we have analyzed. Cite this article as: Radovanović-Dinić B, Tešić-Rajković S, Tešić-Rajković S, Grgovd S. Thrombin activatable fibrinolysis inhibitor as an indicator of the severity of acute pancreatitis. Turk J Gastroenterol 2018; 29: 488-93. Article Info Published In Journal Turkish Journal of Gastroenterology Volume / Issue Volume 29 · Issue 4 Pages 488-493 History Published Online July 15, 2018 Copyright Copyright (c) 2018 Biljana Radovanović-Dinić, Snezana Tesic-Rajkovic, Aleksandra Ignjatovic, Saša Grgov Affiliations Biljana Radovanović-Dinić Clinic for Gastroenterology and Hepatology, Clinical Centre, Ni?, Serbia; University of Ni? School of Medicine, Ni?, Serbia; Snezana Tesic-Rajkovic Clinic for Gastroenterology and Hepatology, Clinical Centre, Ni?, Serbia Aleksandra Ignjatovic University of Ni? School of Medicine, Ni?, Serbia;Department of Medical Statistics, University of Ni? School of Medicine, Ni?, Serbia Saša Grgov General Hospital, Leskovac, Serbia Cite this Article Radovanović-Dinić, B., Tesic-Rajkovic, S., Ignjatovic, A., & Grgov, S. (2018). Thrombin activatable fibrinolysis inhibitor as an indicator of the severity of acute pancreatitis. Turkish Journal of Gastroenterology, 29(4), 488–493. https://doi.org/10.5152/tjg.2018.17666 Outlines

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