Molecular epidemiology of pediatric respiratory syncytial virus infection in Hungary between 2017 and 2023

Molecular epidemiology of pediatric respiratory syncytial virus infection in Hungary between 2017 and 2023 | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 13 March 2025 V1 Latest version Share on Molecular epidemiology of pediatric respiratory syncytial virus infection in Hungary between 2017 and 2023 Authors : Hajnalka Juhász , Katalin Burián , and Gabriella Terhes 0000-0002-7301-9672 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174187452.26941728/v1 160 views 71 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Our study examined the prevalence, types of human respiratory syncytial virus (HRSV), and sequence variability of the attachment glycoprotein (G) gene among symptomatic children under 18 in Hungary between 2017 and 2023. Methods: We retrospectively determined the type of HRSV strains and analysed their G protein sequence and aminoacid polymorphism in respiratory samples before and after the SARS-CoV-2 pandemic. Results: We confirmed the presence of HRSV-A in 233 (12.74%), HRSV-B in 235 (13.85%), and both in 5 cases (0.27%). The subtype pattern was HRSV-B in 2017 and 2022-2023, and HRSV-A in 2017-2022. The highest HRSV positivity (38%) could be observed between 2018 and 2019, while the lowest was in the 2017-2018 season. The median age of HRSV-positive patients was 7.09 months, and we did not show a significant difference in their median age between the seasons. During the SARS-CoV-2 pandemic, the HRSV season has an earlier onset and longer duration than before. All HRSV-A isolates are classified into the A.D clade, HRSV-B strains have belonged to B.D. clade. We found characteristic mutations in the HRV1 region of the G gene in the HRSV-A A.D strains during the 2019 and 2020 seasons, forming a distinct lineage closely related to only two German isolates. The HRSV-B B.D strains between 2022 and 2023 carried mutations in the HRV2 region, reported from several countries. Discussion: The SARS-CoV-2 pandemic caused changes in the seasonal appearance of HRSV infections. G protein sequence modifications in Hungarian HRSV strains can support the need for their molecular characterisation. Supplementary Material File (figure legend (1).docx) Download 16.71 KB File (molecular epidemiology of hrsv in children under 18 in hungary from 2017 version 1.docx) Download 6.27 MB Information & Authors Information Version history V1 Version 1 13 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords g protein hrsv hungary phylogenetic substitutions Authors Affiliations Hajnalka Juhász Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Orvostudomanyi Kar View all articles by this author Katalin Burián Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Orvostudomanyi Kar View all articles by this author Gabriella Terhes 0000-0002-7301-9672 [email protected] Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Orvostudomanyi Kar View all articles by this author Metrics & Citations Metrics Article Usage 160 views 71 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Hajnalka Juhász, Katalin Burián, Gabriella Terhes. Molecular epidemiology of pediatric respiratory syncytial virus infection in Hungary between 2017 and 2023. Authorea . 13 March 2025. DOI: https://doi.org/10.22541/au.174187452.26941728/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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