Локальный и системный гормональный дисбаланс у пациенток с хроническим эндометритом

Material and methods . The main group consisted of 45 (75.00 ± 5.59 %) females diagnosed with chronic endometritis, the control group - of 15 (25.00 ± 5.59 %) patients without chronic endometritis. Results. Disorders of the reproductive function were statistically significantly more often found in patients of the main group - 42 (93.33 ± 8.98 %) (χ² = 36.82, p < 0.00001), infertility - in 30 (66.67 ± 7.03 %) (χ² = 17.24, p < 0.00001). The estradiol concentration in patients with chronic endometritis was 0.22 (0.19-0.24), in the control group - 0.25 (0.22-0.27) nmol/l (z = -2.49, p = 0.01). Expression of estrogen receptors in the main group was 95.30 % (92.30-95.30 %), in the control group - 78.70 % (76.00-78.00 %) (z = 3.57, p = 0.0003). Conclusion. Low estrogen levels at the systemic level and high expression of estrogen receptors in the endometrium in female patients with chronic endometritis leads to high incidence rate - 93.3 % of reproductive dysfunction.