In-Vivo Assessment of Movement-Evoked Pain using Digital Technology in Patients with Chronic Back Pain: Implications for treatment personalization

In-Vivo Assessment of Movement-Evoked Pain using Digital Technology in Patients with Chronic Back Pain: Implications for treatment personalization | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Brief Communication In-Vivo Assessment of Movement-Evoked Pain using Digital Technology in Patients with Chronic Back Pain: Implications for treatment personalization Madelyn Frumkin, Jacob Greenberg, Justin Zhang, Saad Javeed, Jingwen Zhang, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3892271/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Digital methods are increasingly used to monitor activity and pain, yet few studies combine data streams to assess clinically relevant constructs, such as movement-evoked pain (MEP). In this study of patients with chronic back pain being evaluated for spine surgery, in-vivo assessment of MEP was uncorrelated with pre-surgical pain, interference, or physical function. In support of our hypothesis, however, patients exhibiting greater preoperative MEP demonstrated greater improvement in pain interference one month after spine surgery. Digital technology can be leveraged to improve treatment recommendations for patients with chronic pain. Health sciences/Risk factors Health sciences/Medical research Full Text Additional Declarations There is a conflict of interest MRF reports consulting for Blueprint Health but declares no non-financial competing interests. WZR reports consulting for Globus, DePuy Synthes, Nuvasive, Corelink, and Pacira, and serving as patent holder with Acera but declares no non-financial competing interests. All other authors declare no financial or non-financial competing interests. This study was approved by the Institutional Review Board at Washington University in St. Louis (IRB #202012139). Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3892271","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Brief Communication","associatedPublications":[],"authors":[{"id":270474183,"identity":"7714a42f-fa2e-418a-a547-b9881c345643","order_by":0,"name":"Madelyn 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