Use of pre-operative GnRH-analogue to predict pain outcome following hysterectomy with or without oophorectomies for chronic pelvic pain

Melanie Pillay, Cheryl Yim, Lauren Hicks, Claudia Cheng, Martin Healey
In: Journal of Endometriosis and Pelvic Pain Disorders · 2025 · vol. 18(1) , pp. 3–10 · doi:10.1177/22840265251366382 · W4414191376
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Pre-operative gonadotrophin-releasing hormone analogue treatment accurately predicted post-surgical pain outcomes in patients undergoing hysterectomy and/or oophorectomies for chronic pelvic pain.

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The provided text contains only metadata, publication details, and access options for an article titled "Use of pre-operative GnRH-analogue to predict pain outcome following hysterectomy with or without oophorectomies for chronic pelvic pain." It does not include the abstract, methods, results, or conclusion sections necessary to summarize the study's actual findings or methodology. Consequently, no specific data regarding patient populations, interventions, or outcomes can be extracted from the available content. Relevance to endometriosis: The paper title suggests a focus on chronic pelvic pain management potentially involving conditions like endometriosis, but the lack of abstract text prevents confirmation of this relationship.

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Abstract

Introduction: Chronic pelvic pain (CPP) is a common and variable condition often without standardised or effective treatment. A hysterectomy and/or oophorectomies alleviates CPP long term in some patients. Gonadotrophin releasing hormone analogues (GnRHa) induce a pseudo-menopausal state, mimicking some outcomes of these surgical procedures. This study aims to examine whether the use of pre-operative GnRHa can predict the pain outcome of patients undergoing hysterectomy and/or oophorectomies for CPP. Methods: This is a retrospective cohort study at a tertiary university-affiliated hospital between 2010 and 2019 inclusive. Of 647 patients screened, 56 met the inclusion criteria of (i) pre-operative GnRHa prescription for pain management and (ii) proceeding to hysterectomy and/or oophorectomies. A positive pain response was considered either partial or complete pain relief. Results: All patients ( N = 16) who had complete pain relief with GnRHa had complete pain resolution after surgery. Of the 25 patients who had partial resolution of pain with GnRHa, 22 (88.0%) had a positive pain response post-surgery. One patient reported no pain relief with either intervention. Pre-operative GnRHa had a sensitivity of 90.5% and specificity of 100% in predicting pain outcomes post hysterectomy and/or oophorectomies in this study. Conclusion: Pre-operative GnRHa may be useful in patients with CPP to predict pain outcome after hysterectomy and/or oophorectomies.
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