Pulmonary endometriosis 25 years after surgical menopause (clinical case report)

In: Journal of obstetrics and women's diseases · 2023 · vol. 72(5) , pp. 137–145 · doi:10.17816/jowd569225 · W4388936488
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This case report describes widespread pulmonary endometriosis 25 years after surgical menopause, suggesting potential reactivation of the disease and exploring aromatase inhibitors as a postmenopausal treatment strategy.

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This clinical case report describes widespread pulmonary endometriosis in a 65-year-old woman presenting 25 years after surgical menopause, with a prior history of widespread genital and extragenital endometriosis including ureter involvement. The authors note that menopausal hormone therapy was not used and suggest this may relate to disease recurrence/reactivation, with concern raised by lung lesions plus a pelvic infiltrate and by altered estrogen metabolism in implants alongside low peripheral estradiol levels. They discuss aromatase inhibitors as a potential postmenopausal strategy grounded in the metabolic characteristics of endometriosis tissue, while the principal limitation is the single-case design and the paper’s focus on clinical history rather than systematic testing. This paper is centrally about endometriosis — specifically a case of pulmonary endometriosis arising/reappearing decades after surgical menopause and the discussion of postmenopausal endocrine mechanisms and treatment rationale.

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Abstract

A clinical case of widespread pulmonary endometriosis in a 65-year-old woman 25 years after surgical menopause is exposed. It is known from the history that earlier patient had endometriosis, as well as extragenital endometriosis involving the ureters. Conspicuous is the fact that menopausal hormone therapy was not prescribed, which could explain the recurrence of the disease. However, the presence of extragenital endometriosis lesions in the lungs and pelvic endometriotic infiltration may indicate reactivation of endometriosis. Taking into account the altered metabolism of estrogens in the endometriosis implants and low level of estradiol in peripheral blood, the use of aromatase inhibitors may be one of the strategies for the treatment of common forms of endometriosis, including extragenital, in the postmenopausal period.
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Widespread pulmonary endometriosis 25 years after surgical menopause. A case report - Authors: Yarmolinskaya M.I.1, Suslova E.V.1 - Affiliations: - The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott - Issue: Vol 72, No 5 (2023) - Pages: 137-145 - Section: Clinical practice guidelines - Submitted: 12.09.2023 - Accepted: 10.10.2023 - Published: 23.11.2023 - URL: https://journals.eco-vector.com/jowd/article/view/569225 - DOI: https://doi.org/10.17816/JOWD569225 - ID: 569225 Cite item Abstract We herein present a clinical case of widespread pulmonary endometriosis in a 65-year-old woman 25 years after surgical menopause. The patient is known from the history to have had widespread genital and extragenital endometriosis involving the ureters. Conspicuous is the fact that menopausal hormone therapy was not prescribed, which could account for the recurrence of the disease. However, the presence of extragenital endometriosis lesions in the lungs and an infiltrate in the pelvis may indicate reactivation of the disease. Taking into account the altered metabolism of estrogens in the endometriosis implants and the low level of estradiol in peripheral blood, the use of aromatase inhibitors may be a strategy for the treatment of common forms of endometriosis, including extragenital one, in the postmenopausal period. Full Text About the authors Maria I. Yarmolinskaya The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott Email: [email protected] ORCID iD: 0000-0002-6551-4147 SPIN-code: 3686-3605 MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences Russian Federation, St. PetersburgElena V. Suslova The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott Author for correspondence. Email: [email protected] ORCID iD: 0000-0002-2861-873X SPIN-code: 8986-9303 MD, Cand. Sci. 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