Inconsistent Rebound of Invasive Pneumococcal Disease in Connecticut following the Initial Phase of the SARS-CoV-2 Pandemic

The incidence of invasive pneumococcal disease (IPD) decreased during the SARS-CoV-2 pandemic and rebounded inconsistently over 2 years, with occasional returns to pre-pandemic levels followed by subsequent declines. We evaluated several explanations including changes in rates of viral infections that could interact with pneumococcus and changes in blood culture practices.