Forest plot of pooled OR with 95% CI for association between the null genotype of GSTM1 and endometriosis risk.

Haili Zhu (627931), Jiming Bao (627932), Shuguang Liu (87095), Qing Chen (131379), Hong Shen (166278)
2015 · doi:10.1371/journal.pone.0106761.g002 · W6942011944
other OA: green CC0
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This meta-analysis of 25 case-control studies investigated the association between null genotypes of glutathione S-transferase genes, specifically GSTM1 and GSTT1, and the risk of developing endometriosis. The authors pooled data to calculate odds ratios with 95% confidence intervals, utilizing forest plots to visualize the statistical significance of these genetic variants across different populations. The results indicated a significant correlation between the GSTM1 null genotype and increased susceptibility to endometriosis, while the association for GSTT1 was less pronounced or inconsistent across the included studies. This paper is centrally about endometriosis — specifically examining the role of genetic polymorphisms in disease etiology and risk stratification.

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Forest plot of pooled OR with 95% CI for association between the null genotype of GSTM1 and endometriosis risk.
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Null Genotypes of GSTM1 and GSTT1 and Endometriosis Risk: A Meta-Analysis of 25 Case-Control Studies Figure 2 Forest plot of pooled OR with 95% CI for association between the null genotype of GSTM1 and endometriosis risk. Skip to main content Advertisement Browse Subject Areas ? Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click here. Forest plot of pooled OR with 95% CI for association between the null genotype of GSTM1 and endometriosis risk.

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