Gonadotrapin-releasing hormone agonist for the treatment of infertility complicated with adenomyosis

Objective To study the effect of gonadotropin-releasing hormone agonist (GnRH-a) on infertility complicated with adenomyosis. Methods GnRH-a and sex-steroid add-back therapy were used for twelve patients with infertility complicated with adenomyosis with a dosage of 3.75mg/m for6 months.After withdrawing the GnRH-a,assisted reproductive technology (ART) was used in some of them.Examinations for B-ultra sonography (B-us),MRI,BMD,blood CA125 and sexual hormone were done before and after the therapy. Results After the treatment,the symptom of dysmenorrhea was relieved. B-us and MRI showed focus of adenomyosis disappeared and the volume and size of uteri recovered in 83.33% .The levels of blood CA125 ,FSH,LH,EI decreased significantly ( P 0.01 ). Lumber bone marrow density (L-BMD) had no significant changes (P0.05) .The pregnant rate was 75.0%. Conduaons GnRH-a seams effective for the treatment of infertility with adenomyosis. The pregnant rate can be improved significantly with ART. HRT is considered necessary when using GnRH-a.