Factors Correlated with Long-term Weight Loss and DM Remission after Laparoscopic Sleeve Gastrectomy

Background: The aim of this study is to investigate the factors correlated with long-term weight loss and diabetes mellitus (DM) remission after laparoscopic sleeve gastrectomy (LSG). Methods Sixteen obese patients who underwent LSG were enrolled in this study (male/female: 5/11, mean age: 44.0 years, mean body weight: 127.5 kg, mean body mass index: 47.4 kg/m 2 , DM: n  = 11). We investigated the percent excess weight loss (%EWL), %TWL, and DM remission 3 years post-operation and the factors correlated with long-term weight loss and DM remission after LSG. Results The %EWL 3 years post-operation was 49.6%, while the %TWL was 24.0%. Complete remission (CR) of DM was 54.5% and an improvement occurred in 18.2% of cases 3 years post-operation, whereas there was no change in 27.3% of cases. The factor correlated with a %EWL ≥ 50% 3 years post-operation was a better %EWL at 1 year post-operation. Factors correlated with DM remission 3 years post-operation were a low preoperative neutrophil-lymphocyte ratio and DiaRem score and CR or partial remission 1 year post-operation. Conclusion Regarding long-term weight loss after LSG, better weight loss 1 year post-operation was important. In terms of long-term DM remission, a low preoperative neutrophil-lymphocyte ratio and DiaRem score and achieving CR or partial remission 1 year post-operation were key factors.