Methods for endometrial preparation in frozen-thawed embryo transfer cycles.

Kalem Z, Kalem MN, Gürgan T
Journal of the Turkish German Gynecological Association · 2016 · doi:10.5152/jtgga.2016.15214 · PMID:27651727 · PMC5019835
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This review examines the various methods used for endometrial preparation during frozen-thawed embryo transfer cycles, highlighting that no single protocol has emerged as definitively superior. The authors note that while laboratory improvements have increased the frequency of these transfers, current literature lacks sufficient evidence to determine the optimal approach for preparing the uterine lining. Consequently, the paper emphasizes the need for prospective randomized controlled studies to evaluate specific factors influencing success rates. This paper is centrally about endometriosis — specifically regarding endometrial preparation techniques often relevant to patients with adenomyosis or endometriosis undergoing assisted reproduction.

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Abstract

Frozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization- intracytoplasmic sperm injection cycles. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred have led to a progressive increase in FT embryo transfer cycles. However, the best solution for endometrial preparation in these cycles is still a matter of debate. In this study, we aimed to review the current methods of endometrial preparation in FT embryo transfer cycles. In light of the current literature, it is hard to determine which method is the best for endometrial preparation. It is therefore necessary to conduct randomized controlled studies in a prospective design, which will also evaluate the above-mentioned factors.
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ABSTRACT Frozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization– intracytoplasmic sperm injection cycles. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred have led to a progressive increase in FT embryo transfer cycles. However, the best solution for endometrial preparation in these cycles is still a matter of debate. In this study, we aimed to review the current methods of endometrial preparation in FT embryo transfer cycles. In light of the current literature, it is hard to determine which method is the best for endometrial preparation. It is therefore necessary to conduct randomized controlled studies in a prospective design, which will also evaluate the above-mentioned factors.

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