Clear cell carcinoma of the ovary: potential pathogenic mechanisms (Review)

Print ISSN: 1021-335X Online ISSN: 1791-2431 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Review - Authors: - Pages: 1193-1203|Published online on: May 1, 2010https://doi.org/10.3892/or_00000750 - Expand metrics + Epithelial ovarian cancer (EOC) is the most common cause of gynecological cancer-related mortality. Clear cell EOC (cEOC) has a number of clinical features distinguishing it from other EOC because of frequent concurrence of endometriosis and highly chemoresistant nature resulting in a poor prognosis. Recent biochemical studies based on genome-wide expression analysis technology have noted specific expression of a transcription factor, hepatocyte nuclear factor-1β (HNF-1β), in cEOC and genetic alteration may be involved in oxidative stress. We describe the HNF-1β-dependent pathophysiology of cEOC and discuss its role in oxidative stress-induced carcinogenesis. A systematic search was performed in the electronic databases PubMed and ScienceDirect up to July 2009, combining the keywords, genome-wide, microarray, epithelial ovarian cancer, clear cell carcinoma, oxidative stress, and detoxification, with specific expression profiles of genes. The catalog of cEOC-specificity might be a manifestation of six essential alterations in cell physiology: oxidative stress and detoxification, proteases, signal transduction, adhesion, transcription, and metabolism. Among 54 genes highly upregulated in cEOC, 47 genes (87.0%) were associated with the redox-related genes. Several important cEOC-related genes overlap with those known to be regulated by HNF-1β. Twenty-two (40.7%) of the 54 genes predominantly identified in cEOC were involved in downstream targets of HNF-1β. The HNF-1β-dependent pathway might provide new insights into regulation of glycogen synthesis, detoxification and resistance to anticancer agents. This review summarizes recent advances in the understanding of oxidative stress and antioxidant mechanisms in pathogenesis of cEOC. A redox-sensitive subset of cEOC genes linked to oxidative and detoxification pathways was identified and associated with HNF-1β-specific downstream targets. Copy and paste a formatted citation Spandidos Publications style Kajihara H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H, Kobayashi H, et al: Clear cell carcinoma of the ovary: Potential pathogenic mechanisms (Review). Oncol Rep 23: 1193-1203, 2010. APA Kajihara, H., Yamada, Y., Kanayama, S., Furukawa, N., Noguchi, T., Haruta, S. ... Kobayashi, H. (2010). Clear cell carcinoma of the ovary: Potential pathogenic mechanisms (Review). Oncology Reports, 23, 1193-1203. https://doi.org/10.3892/or_00000750 MLA Kajihara, H., Yamada, Y., Kanayama, S., Furukawa, N., Noguchi, T., Haruta, S., Yoshida, S., Sado, T., Oi, H., Kobayashi, H."Clear cell carcinoma of the ovary: Potential pathogenic mechanisms (Review)". Oncology Reports 23.5 (2010): 1193-1203. Chicago Kajihara, H., Yamada, Y., Kanayama, S., Furukawa, N., Noguchi, T., Haruta, S., Yoshida, S., Sado, T., Oi, H., Kobayashi, H."Clear cell carcinoma of the ovary: Potential pathogenic mechanisms (Review)". Oncology Reports 23, no. 5 (2010): 1193-1203. https://doi.org/10.3892/or_00000750