Diethylstilbestrol exposure in utero and endometriosis in infertile females

R J Stillman, Robert J. Stillman, L C Miller, Lo-Rita C. Miller
Fertility and Sterility · 1984 · doi:10.1016/s0015-0282(16)47713-7 · PMID:6230258
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Abstract

Endometriosis was found in 39% and in utero diethylstilbestrol (DES) exposure in 5% of 397 infertile women who had undergone laparoscopy and/or laparotomy among 750 consecutively evaluated infertile couples. Fifty percent of the DES-exposed infertile women also had endometriosis, similar to the 39% with endometriosis among non-DES-exposed women. Cervical stenosis was found in 25% of all DES-exposed patients and in 83% of those who had undergone cryocautery or conization. However, 40% did not have endometriosis. Thus, while the frequency of endometriosis and cervical stenosis is extremely high in infertile women exposed in utero to DES, a significant association beyond that found in non-DES-exposed patients could not be established. Some of the infertility may be associated with cervical stenosis alone.

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Condition tags

endometriosisinfertility

MeSH descriptors

Diethylstilbestrol Endometriosis Infertility, Female Prenatal Exposure Delayed Effects Abortion, Spontaneous Abortion, Spontaneous Diethylstilbestrol Endometriosis Endometriosis Female Humans Infertility, Female Laparoscopy Laparotomy Male Pregnancy

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