How can I integrate iEEG recordings with patients’ brain anatomy?

Preparing intracranial electroencephalography (iEEG) datasets for analysis presents a unique set of methodological challenges that are absent in non-invasive investigative techniques. Because iEEG is primarily used in epilepsy patients with varying brain pathologies, the main challenges pertain to variability in electrode coverage and therefore the regions of the brain from which electrophysiological recordings can be obtained. In this chapter, we outline how to efficiently integrate the raw anatomical images and electrophysiological recordings during preprocessing, allowing iEEG datasets to be analyzed in an anatomically precise and consistent way.