Inhibition by sildenafil of contractility of isolated non-pregnant human myometrium

Aruldhas Blessed Winston, Kaysina Vazhudhi, Sumalya Sen, E Thomas, Santhosh Benjamin, Jacob Peedicayil
In: Journal of Pharmacology and Pharmacotherapeutics · 2015 · vol. 6(3) , pp. 136–141 · doi:10.4103/0976-500x.162020 · PMID:26311996 · PMC4544134 · W2245774859
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Abstract

OBJECTIVE: To investigate the ability of sildenafil to inhibit the contractility of isolated non pregnant human myometrium. MATERIALS AND METHODS: The inhibitory effect of three concentrations (3, 10, and 30 µM) of sildenafil on 55 mM KCl-induced contractility of isolated non-pregnant human myometrium was studied. The ability of the guanylyl cyclase inhibitor ODQ (10 µM), the adenylyl cyclase inhibitor MDL-12,330A (10 µM), the non-specific potassium channel blocker TEA (2 mM), and the calcium-sensitive potassium (BKCa) channel blocker iberiotoxin (100 nM) to reverse the inhibition of 10 µM sildenafil on KCl-induced myometrial contractility was also studied. RESULTS: Sildenafil produced a concentration-dependent inhibition of KCl-induced myometrial contractility that was statistically significant at all three concentrations of sildenafil used. The inhibition by 10 µM sildenafil of KCl-induced myometrial contractility was not reversed by the concurrent administration of ODQ or MDL-12,330A. The inhibition of 10 µM sildenafil of myometrial contractility was partially reversed by concurrent administration of TEA and totally and significantly reversed by the concurrent administration of iberiotoxin. CONCLUSIONS: These results suggest that sildenafil inhibits the contractility of isolated non-pregnant human myometrium. The results suggest that sildenafil does so by opening BKCa channels.

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