Advances in Animal Models of Endometriosis

Endometriosis is a common disease in gynecology,and it is one of the main reason that cause pelvic pain and infertility of women in childbearing age. The pathogenesis of endometriosis is unclear and the treatment is inadequate. The establishment and application of models in vivo and in vitro is an important way to explore the occurrence,development and treatment measures of endometriosis. Surgical methods of establishing animal models of endometriosis mainly included homograft and heterograft. Homologous model was established by transplanting uterine fragments into the peritoneal cavity of syngeneic non-human primates and rodents. Heterologous model was established by engrafting human eutopic or ectopic endometrial tissues into the immunodeficient mice or the chicken chorioallantoic membrane(CAM). This article summarizes the construction methods of commonly used models of endometriosis including non-human primates model,rodents model and CAM model,and analyzes the advantages and disadvantages of them to provide a guidance for selection and application of models in experiments.