Does metoclopramide exposure alter endometrial receptivity and decrease pregnancy rates?

Yasemin Çekmez; Vakkaş Korkmaz; Vakkas Korkmaz; Aslı Çakır; Ahmet Göçmen; Yusuf Ergün; Serdar Gülşen; Yasam K Akpak; Yaşam Kemal Akpak

doi:10.3109/14767058.2015.1102221

Does metoclopramide exposure alter endometrial receptivity and decrease pregnancy rates?

Yasemin Çekmez, Vakkaş Korkmaz, Vakkas Korkmaz, Aslı Çakır, Ahmet Göçmen, Yusuf Ergün, Serdar Gülşen, Yasam K Akpak, Yaşam Kemal Akpak

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2015 · vol. 29(16) , pp. 1–4 · doi:10.3109/14767058.2015.1102221 · PMID:26421644 · W2177426384

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Metoclopramide exposure, particularly at high doses, reduced embryo implantation and altered endometrial receptivity by downregulating integrin β3 expression in pregnant rats.

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Abstract

OBJECTIVE: The aim of this study was to investigate the effect of metoclopramide on endometrial receptivity with an immunohistochemical investigation of integrin β3 expression in pregnant rats. MATERIALS AND METHODS: In the present study, the pregnant mice administrated by different doses of metoclopramide were used to explore the effect of metoclopramide on embryo implantation, especially on the endometrial receptivity. RESULTS: The statistical results showed that the number of implanted embryos was gradually declining along the increasing dose of metoclopramide. When the administrated dose of metoclopramide was 3 mg/kg per day, great changes were observed in the exposed uterine morphology and down-regulated integrin β3 were also found in high dose metoclopramide-exposed mice. CONCLUSION: Metoclopramide exposure, especially in high doses may alter endometrial receptivity by effecting integrin expression on decidual tissue which can decrease pregnancy rates. This drug should only be recommended for use during pregnancy when benefit outweighs the risk.

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MeSH descriptors

Embryo Implantation Endometrium Metoclopramide Animals Embryo Implantation Endometrium Endometrium Endometrium Female Immunohistochemistry Integrin beta3 Integrin beta3 Metoclopramide Metoclopramide Pregnancy Rats

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Cites (2)

References (17)

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[1] Implantation defects in infertile women with endometriosis 2002

[2] Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation 2009