Genomic DNA Needs an Electronic Circuit

DNA functions, including rapid gene response, conformational changes, and chromosomal structuring, could be regulated by an electronic circuit. The winding of strands around histones can also be attributed to an electronic effect. Mitochondria are recognized as the power source for cell functions, while semiconductive properties to the nucleobases of DNA strands are controverse. Nuclear Aggregates of Polyamines (NAPs), supramolecular compounds formed by the interaction of polyamines (putrescine, spermidine, and spermine) with phosphate ions, are credible candidates to form hybrid structures with DNA which support electron conduction. The final effect of their assembly is the formation of nanotubes that envelop the DNA and assist the strands in their functions. Furthermore, NAPs show the typical structure of an organic semiconductor, having an aromatic-like arrangement of their monomeric rings and a pseudo-phosphorene nanoribbon disposition of the phosphates located at their apical region. We point to these compounds as a key for a more complete understanding of cell nucleus physiology and as potential models for the development of organic electronic nanodevices.