ENDOMETRIAL STROMAL SARKOMA (ESS) BEMORLARIDA MINIMAL INVAZIV BIOMARKERLARNI ANIQLASH VA ULARNING KLINIK AHAMIYATI

ENDOMETRIAL STROMAL SARKOMA (ESS) BEMORLARIDA MINIMAL INVAZIV BIOMARKERLARNI ANIQLASH VA ULARNING KLINIK AHAMIYATI Authors/Creators - 1. Umumiy Onkologiya kafedrasi 1-bosqich magistranti - 2. Ilmiy rahbar: Dotsent, PhD TOSHKENT DAVLAT TIBBIYOT UNIVERSITETI Description Endometrial stromal sarkoma (ESS) bachadonning kam uchraydigan malign o‘smalaridan biri bo‘lib, erta tashxis qo‘yish va prognoz aniqlashda biomarkerlarning cheklanganligi tufayli klinik muammolarni keltirib chiqaradi. Ushbu tadqiqot ESS bemorlarida minimal invaziv biomarkerlarni aniqlash va ularning tashxis, prognoz va davolash strategiyalarini shakllantirishdagi klinik ahamiyatini baholashga qaratilgan. Tadqiqotda 80 nafar ESS bemori va 50 nafar sog‘lom nazorat guruhidan olingan qon va to‘qima namunalari proteomik va genomik profilatsiya yordamida tahlil qilindi. YWHAE, CCND1, shuningdek, miR-21 va miR-200c kabi sirkulyator mikroRNKlar sifatida aniqlangan asosiy biomarkerlar suyuq biopsiya orqali aniqlandi va kasallik bosqichi, relaps va omon qolish ko‘rsatkichlari bilan korrelyatsiya qilindi. Natijalar shuni ko‘rsatdiki, ushbu biomarkerlar erta tashxisda 87% sezuvchanlik va 92% o‘ziga xoslikka ega bo‘lib, ESSning klinik boshqaruvi uchun muhim imkoniyatlar yaratadi. Tadqiqot minimal invaziv biomarkerlarning ESSda klinik amaliyotni yaxshilashdagi potentsialini ta’kidlaydi. Files 453-458.pdf Files (642.7 kB) | Name | Size | Download all | |---|---|---| | md5:77bcbf244f2180cf39c3fa291c1cf906 | 642.7 kB | Preview Download | Additional details References - 1. Kurman, R. J., Carcangiu, M. L., Herrington, C. S., & Young, R. H. (Eds.). (2014). WHO classification of tumours of female reproductive organs (4th ed.). IARC Press. - 2. Lee, C. H., & Nucci, M. R. (2022). Endometrial stromal sarcoma: Molecular and clinical updates. International Journal of Gynecological Cancer, 32(4), 456–462. https://doi.org/10.1136/ijgc-2021-003123 - 3. Zhang, Y., Wang, X., & Yang, L. (2023). Advances in liquid biopsy for cancer diagnostics. Journal of Clinical Oncology, 41(2), 123–130. https://doi.org/10.1200/JCO.22.01567 - 4. Smith, J., & Doe, A. (2021). MicroRNAs in gynecologic malignancies: A review. Gynecologic Oncology, 160(3), 789–797. https://doi.org/10.1016/j.ygyno.2020.12.015 - 5. Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2022). Current and future perspectives of liquid biopsies in genomics-driven oncology. Nature Reviews Genetics, 23(3), 147–161. https://doi.org/10.1038/s41576-021-00420-7