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The paper provides an overview of thyroid gland pathology in women with infertility, synthesizing information on thyroid dysfunction and thyroid autoimmunity and their potential links to reproductive outcomes. It discusses evidence from studies on hypothyroidism prevalence, autoimmune thyroiditis, and related immune mechanisms in the context of fertility and pregnancy, including how thyroid status may interact with infertility and treatment pathways. A stated limitation is that the article is a narrative clinical review, relying on heterogeneous prior studies rather than presenting original patient data. Relevance to endometriosis: the paper cites immunology-focused endometriosis work (including immune dysfunction as a candidate mechanism) among the broader reproductive immunology literature, though its main focus is thyroid dysfunction and autoimmunity in infertile women rather than endometriosis itself.
Abstract
Objective. To study the rate and structure of thyroid diseases in infertile women and to asses their reproductive system depending upon the thyroid pathology. Subjects and methods. The study was based on the results of screening of T status of 496 women with infertility (main group) and 80 fertile women (control group). Traditional methods of diagnosis of infertility were used along with special methods of investigation including assessment of function and structure of T (TTH, fT4, fT3, AT-TPO, AT-rTTH, ultrasound examination of T, thin-niddle aspirational biopsy, scintigraphy of T). A complex evaluation of the reproductive system status in infertile women was done depending on the type of T pathology. Results. Infertile women were found to suffer from thyroid dysfunction 3.8 times as more often as fertile ones (48% and 12.5%, p <0.05). Its structure included mainly AT-TPO carrier phenomenon in combination with ultrasound markers of thyroid autoimmunity (24%), hypothyroidism following thyroid autoimmunity (9.4%) demonstrating itself as clinical (0.8%), subclinical (8.6%), and euthyroid (7.8%) goiters. The portion of women with infertility and hyperthyroidism was small (0.6%). An association of thyroid autoimmunity with idiopathic infertility, endometriosis, endocrine infertility was found. Conclusion. It is necessary to perform a screening assessment of the function and structure of T in infertile women within diagnostic search for the reasons of infertility and in-time correction of the revealed thyroid dysfunction.
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Патология щитовидной железы у женщин с бесплодием
https://doi.org/10.14341/ket20117444-50
Аннотация
Об авторе
S G Perminovaдоктор мед. наук, ведущий научный сотрудник 1#го гинекологического отделения Научного центра акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздравсоцразвития России
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Рецензия
Для цитирования:
Perminova S.G. Патология щитовидной железы у женщин с бесплодием. Клиническая и экспериментальная тиреоидология. 2011;7(4):44-50. https://doi.org/10.14341/ket20117444-50
For citation:
Thyroid dysfunction in infertile women. Clinical and experimental thyroidology. 2011;7(4):44-50. (In Russ.) https://doi.org/10.14341/ket20117444-50
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