VEGF、MMP-7在子宫内膜异位症中的表达及意义

In: 泰山医学院学报 · 2011 · vol. 32(2) , pp. 107–109 · W894132854
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Abstract

目的探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)、基质金属蛋白酶-7(mauixmet-alloproteinases-7,MMP-7)在在正常人及子宫内膜异位症(endometriosis,EMT)患者内膜组织中的表达,探讨VEGF、MMP-7在EMT发生发展中的作用。方法通过免疫组化S-P法分别检测MMP-7及VEGF在EMT患者在位子宫内膜及异位内膜和正常子宫内膜中的表达。结果异位内膜MMP-7表达与在位内膜无差异,但高于正常内膜(P〈0.05),在位内膜与正常子宫内膜相比,差异有显著性(P〈0.05);卵巢异位内膜VEGF表达与同期在位内膜相比,表达增高,差异有显著性(P〈0.05),且明显高于正常内膜(P〈0.005);在位内膜与正常子宫内膜相比,VEGF表达差异无显著性(P〉0.05)。结论 EMT在位内膜、异位内膜中VEGF及MMP-7与异位内膜的高侵袭性和高血管新生能力有关,在EMs的发生发展中起重要作用。

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endometriosis

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