Pathological Study about Positive Cell of Leptin and Vascular Endothelial Growth Factor in Ovarian Endometriosis

[Objective] To discuss the pathophysiological role of leptin and vascular endothelial growth factor (VEGF) in endometriosis. [Methods] Leptin and VEGF expression were detected in 28 ectopic endometrium, eutopic endometrium, and 20 endometrium of control group by immunohistochemical staining. [Results]Ectopic and eutopic tissues showed statistically stronger leptin and VEGF expression compared with normal controls (P 0.05) and ectopic tissues showed statistically stronger leptin and VEGF expression compared with eutopic tissues (P 0.01) in glandular epithelium cells; Ectopic tissues showed statistically stronger leptin expression compared with eutopic tissues, normal controls in stroma cells (P 0.01). However, we did not find difference about VEGF expression among ectopic tissues, eutopic tissues, or normal controls in stroma cells(P﹥0.05). Leptin expression was positively correlated to VEGF expression in ectopic endometrium and eutopic endometrium (P 0.01). [Conclusions] Leptin and VEGF play an important role in the progression of endometriosis. There is close relationship between leptin, VEGF, and endometriotic angiogenesis.