Causal Relationship between Subacute Thyroiditis and Papillary Thyroid Cancer: a two-sample Mendelian Randomization Analysis

Causal Relationship between Subacute Thyroiditis and Papillary Thyroid Cancer: a two-sample Mendelian Randomization Analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Causal Relationship between Subacute Thyroiditis and Papillary Thyroid Cancer: a two-sample Mendelian Randomization Analysis Shengcan Zhang, Hui Ye, Wei Li, Xue Gu, Xinyu Zhai This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6695976/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background According to clinical studies, Subacute Thyroiditis and Papillary Thyroid Cancer are two diseases with high incidence in thyroid diseases. Although there are reports of coexistence between them, the link between the two is still unknown. Therefore, we used a two-sample Mendelian randomization (MR) method to evaluate the causal effect of subacute thyroiditis on papillary thyroid carcinoma (PTC). Method The FinnGen database was used as the data source, and P < 5x10-8 was used as the threshold to screen the single nucleotide polymorphism (SNP) of subacute thyroiditis as an instrumental variable. MR-Egger, weighted median method, inverse variance weighting (IVW), simple mode and weighted mode were used to evaluate the causal association between subacute thyroiditis and papillary thyroid carcinoma using selected instrumental variables. Result According to inverse variance weighting (IVW) analysis, there is a causal relationship between subacute thyroiditis (SAT)and papillary thyroid carcinoma (PTC), in which SAT has a protective effect on PTC. The occurrence of SAT significantly reduced the incidence of PTC (OR = 0.876; 95% CI: 0.807,0.952; p = 0.002). Egger intercept test and Cochran 's Q test showed that the results of IVW analysis were reliable. Conclusion The causal link between SAT and PTC was established through MR analysis, and it was also found that SAT reduced the incidence of PTC. Subacute thyroiditis Papillary Thyroid Cancer Mendelian Randomization Thyroid Diseases Single Nucleotide Polymorphism Full Text Additional Declarations No competing interests reported. Supplementary Files supplementary.docx CCBE1GO.pdf CCBE1KEGG.pdf ZSCAN12.pdf ZSGO.pdf ZSKEGG.pdf consensusclustering1.png consensusclustering2.png consensusclustering3.png consensusclustering4.png clusterxcell.pdf CCBE1.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6695976","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":467638819,"identity":"4915ab89-1ccd-488c-b5ff-4c8bf0471558","order_by":0,"name":"Shengcan Zhang","email":"","orcid":"","institution":"Clinical Medical College, Guizhou Medical University, Guizhou, China","correspondingAuthor":false,"prefix":"","firstName":"Shengcan","middleName":"","lastName":"Zhang","suffix":""},{"id":467638820,"identity":"5909432b-21fe-4b5f-9177-e8fd9559b9c6","order_by":1,"name":"Hui 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Analysis","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Subacute thyroiditis, Papillary Thyroid Cancer, Mendelian Randomization, Thyroid Diseases, Single Nucleotide Polymorphism","lastPublishedDoi":"10.21203/rs.3.rs-6695976/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6695976/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eAccording to clinical studies, Subacute Thyroiditis and Papillary Thyroid Cancer are two diseases with high incidence in thyroid diseases. Although there are reports of coexistence between them, the link between the two is still unknown. Therefore, we used a two-sample Mendelian randomization (MR) method to evaluate the causal effect of subacute thyroiditis on papillary thyroid carcinoma (PTC).\u003c/p\u003e\u003ch2\u003eMethod\u003c/h2\u003e \u003cp\u003eThe FinnGen database was used as the data source, and P\u0026thinsp;\u0026lt;\u0026thinsp;5x10-8 was used as the threshold to screen the single nucleotide polymorphism (SNP) of subacute thyroiditis as an instrumental variable. MR-Egger, weighted median method, inverse variance weighting (IVW), simple mode and weighted mode were used to evaluate the causal association between subacute thyroiditis and papillary thyroid carcinoma using selected instrumental variables.\u003c/p\u003e\u003ch2\u003eResult\u003c/h2\u003e \u003cp\u003eAccording to inverse variance weighting (IVW) analysis, there is a causal relationship between subacute thyroiditis (SAT)and papillary thyroid carcinoma (PTC), in which SAT has a protective effect on PTC. The occurrence of SAT significantly reduced the incidence of PTC (OR\u0026thinsp;=\u0026thinsp;0.876; 95% CI: 0.807,0.952; p\u0026thinsp;=\u0026thinsp;0.002). Egger intercept test and Cochran 's Q test showed that the results of IVW analysis were reliable.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eThe causal link between SAT and PTC was established through MR analysis, and it was also found that SAT reduced the incidence of PTC.\u003c/p\u003e","manuscriptTitle":" Causal Relationship between Subacute Thyroiditis and Papillary Thyroid Cancer: a two-sample Mendelian Randomization Analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-06-09 15:34:48","doi":"10.21203/rs.3.rs-6695976/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"02e27c75-f1b7-4aab-810a-bfc1d6a1cc0c","owner":[],"postedDate":"June 9th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-07-29T09:08:18+00:00","versionOfRecord":[],"versionCreatedAt":"2025-06-09 15:34:48","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6695976","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6695976","identity":"rs-6695976","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}