[PRACTICAL EXPERIENCES WITH OVULATION INHIBITION].

213 patients were treated over 390 cycles with ovulation inhibitors in most cases for therapeutic purposes. No contraceptive failures occurred among 32 patients taking the preparation Anovlar for fertility control over 114 cycles but 2 discontinued because of side effects (vomiting exhaustion). Of 35 severe cases of dysmenorrhea treated with Anovlar 24 women reported cessation of pain and 7 felt an improvement. Comparable results were obtained in hypermenorrhea and polymenorrhea cases. 17 of 19 women with oligomenorrha achieved regular cycles with Anovlar although long-term effects were not observed. In sum of 70 cases of menstrual disorders treated with Anovlar failures occurred with only 10. Ovulation inhibitors may also be useful in treating sterility by alleviating hypoplasia of the uterus and tubes and by fostering a better corpus luteum function. Among 27 women with corpus luteum deficiency 3 conceptions and 10 improvements of corpus luteum function were achieved after 2 cycles. Side effects with Anovlar were infregquent. Also tested in 40 cases were test drugs containing 1 or 2 mg ethinyl estrendiol diacetate and .1 mg ethinyl estradiol methyl ether. Particularly good results were obtained with hypermenorrhea but side effects were relatively frequent with the 1 mg does. Finally 5 patients were treated for endometriosis with Orgametril an ethinyl hydroxyestron. In all cases freedom from pain and considerable remission of the knotty condition were obtained after 7-12 months of treatment. In 2 cases doses of 1 tablet daily resulted in prolonged breakthrough bleeding that disappeared when the amount was increased to 2 tablets. Recurrence was observed in 1 case indicating that a schedule of increasing doses may be desirable. Side effects (some hair loss itching increased acne) were attributed to the effect of long-term treatment on the pituitary. Needed now is an ovulation inhibitor with the lowest possible failure rate fewest possible side effects and no virilizing effect on the fetus in case of an undetected pregnancy. Since these conditions have not yet been met continuing medical monitoring of use of these preparations is necessary.