Renal effects of sulfated polysaccharides from the seaweed Gracilaria cornea

Renal effects of sulfated polysaccharides from the seaweed Gracilaria cornea | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 25 March 2025 V1 Latest version Share on Renal effects of sulfated polysaccharides from the seaweed Gracilaria cornea Authors : terentia Norões 0000-0001-5341-8783 [email protected] , Helena Monteiro , Alice Martins , C.G.L Silva , N.M.B Benevides , and R.P.G. Vieira Authors Info & Affiliations https://doi.org/10.22541/au.174291411.16851131/v1 Published Toxins Version of record Peer review timeline 154 views 67 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Sulfated polysaccharides are widely found in seaweed. These compounds have several commercial uses, especially in the industrial sector. However, the renal effects of these substances remain to be investigated. This work aimed to evaluate the renal effects of the total sulfated polysaccharides (TSP) obtained from the seaweed Gracilaria cornea on the renal system. The TSP significantly increased the perfusion pressure (PP) and the renal vascular resistance (RVR). TSP decreased the urinary flow at the lowest concentration tested but increased at higher concentrations. The TSP caused a significant decrease in the glomerular filtration rate (GFR) and transport of sodium, potassium and chloride. The compounds caused mild histological changes, which indicated tubular and glomerular damages. The TSP caused significantly decreased in the viability of MDCK cells, which presented apoptotic signs and late apoptotic cell death. In conclusion, TSP caused significant changes in renal physiology and morphology. However, further research is required to elucidate the signaling pathways involved in the apoptotic effects of TSP and evaluate the potential of these molecules on drug development. Supplementary Material File (figures gracilaria c_2.docx) Download 869.83 KB File (sulfated polysaccharides gracilaria (1).docx) Download 920.49 KB Information & Authors Information Version history V1 Version 1 25 March 2025 Peer review timeline Published Toxins Version of Record 9 Oct 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations terentia Norões 0000-0001-5341-8783 [email protected] Universidade Federal do Ceara View all articles by this author Helena Monteiro Universidade Federal do Ceara View all articles by this author Alice Martins Universidade Federal do Ceara View all articles by this author C.G.L Silva Universidade Federal do Cariri View all articles by this author N.M.B Benevides Universidade Federal do Ceara View all articles by this author R.P.G. Vieira Universidade Federal do Cariri View all articles by this author Metrics & Citations Metrics Article Usage 154 views 67 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation terentia Norões, Helena Monteiro, Alice Martins, et al. Renal effects of sulfated polysaccharides from the seaweed Gracilaria cornea. Authorea . 25 March 2025. DOI: https://doi.org/10.22541/au.174291411.16851131/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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