Effectiveness of Mirena on Treatment of Adenomyosis:Analysis of 46 Cases

Objective:To evaluate the effects and the side-effects of Mirena on treatment of adenomyosis.Methods:Mirena were inserted into the 46 gravida cases with adenomyosis,on the 5～8th day of menstrual cycle.The menstrual blood loss,dysmenorrhoea scores,hemoglobin,uterine volume,and the levels of serum FSH,LH,E_2 were recorded before insertion,three months and 12 months after insertion respectively.Results:After insertion of Mirena,the menstrual blood loss significantly decreased (P0.01);Amenorrhoea occurred in 18 patients with different duration.But the level of Hemoglobin had no significantly increased (P0.05).The dysmenorrhoea scores became lower,even vanished in some cases.The uterine volume decreased also (P0.05).The serum FSH,LH,and E_2 levels had no marked change (P0.05).Conclusions:Mirena inserting inside uterine cavity can significantly alleviate the clinical symptoms of adenomyosis with no effect on ovarian function.Moreover,it can improve the patients' living quality,and is quite promising in the clinical application.