Imaging of artificial tumor models in an anatomical breast phantom with a single-sided magnetic particle imaging scanner

Imaging of artificial tumor models in an anatomical breast phantom with a single-sided magnetic particle imaging scanner | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Imaging of artificial tumor models in an anatomical breast phantom with a single-sided magnetic particle imaging scanner Alexey Tonyushkin, Christopher McDonough, John Chrisekos, Matthew Jurj, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6486706/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Magnetic Particle Imaging (MPI) is an emerging biomedical imaging modality that detects superparamagnetic iron oxide (SPIO) nanoparticle tracers, providing high contrast, sensitivity, and quantification capabilities without the use of ionizing radiation, making it particularly suitable for cancer diagnostics. Considerable engineering efforts are underway to translate MPI technology to clinical settings. Most of these MPI scanners feature a cylindrical bore geometry similar to other clinical imaging modalities, which restricts their potential application primarily to head scanning. We have developed a single-sided MPI scanner designed to expand the technique's applicability to other regions of the human body. In this study, we demonstrate the imaging capabilities of our single-sided MPI scanner by imaging an anatomical breast phantom with concealed SPIO point sources to evaluate its potential for breast tumor diagnostics. Our method successfully distinguished these artificial tumors in two orthogonal slices, showcasing the scanner's capability to facilitate the transition of MPI technology from small animals to clinical use. Physical sciences/Engineering/Biomedical engineering Physical sciences/Nanoscience and technology/Techniques and instrumentation/Imaging techniques MPI breast cancer imaging nanoparticles Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6486706","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":457205518,"identity":"39d7823b-8ed2-41e2-ad28-b25dbfcf94b5","order_by":0,"name":"Alexey Tonyushkin","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA9ElEQVRIiWNgGAWjYPCCAwZsDMwHgLQFkJPAwMCDRy0PQgsbUOkBCRK0AJkGxGmxZ+89Js3z544xn3TPxwc/zkjIm7MnMD5424bHFp5zadK8bc/M2GTObjbsuSFhuLPnAbPhXHxaJHLMpHkbDtuwSeRuk+D5IMG44UYCG9AQAlp4/oC05DyT/PNBwh6ohf03YS1sh82AWtikeW5IJIJsYcar5cwZY8u5bYeN2STSjI1lzkgkbzjzsFlyzjncWtjbewxvvPlz2HD+jOSHD98cs7HdcDz54Ic3Zbi1AAGLBJoAYwNe9UDA/IGQilEwCkbBKBjhAABwtVGS5AWEIgAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-0531-715X","institution":"Oakland University","correspondingAuthor":true,"prefix":"","firstName":"Alexey","middleName":"","lastName":"Tonyushkin","suffix":""},{"id":457205519,"identity":"f0624da9-c5bf-434e-a0e0-b5d77fa98284","order_by":1,"name":"Christopher McDonough","email":"","orcid":"","institution":"Oakland University","correspondingAuthor":false,"prefix":"","firstName":"Christopher","middleName":"","lastName":"McDonough","suffix":""},{"id":457205520,"identity":"94762f54-b6cc-4121-80ef-b11974eff2b5","order_by":2,"name":"John Chrisekos","email":"","orcid":"","institution":"Oakland University","correspondingAuthor":false,"prefix":"","firstName":"John","middleName":"","lastName":"Chrisekos","suffix":""},{"id":457205521,"identity":"4a80cac3-d8b1-4f2f-8bb5-0f1da8ac4cc7","order_by":3,"name":"Matthew Jurj","email":"","orcid":"","institution":"Oakland University","correspondingAuthor":false,"prefix":"","firstName":"Matthew","middleName":"","lastName":"Jurj","suffix":""},{"id":457205522,"identity":"7b21313e-f04f-4d9d-b33b-95649c70a656","order_by":4,"name":"Alycen Wiacek","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Alycen","middleName":"","lastName":"Wiacek","suffix":""}],"badges":[],"createdAt":"2025-04-19 22:00:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6486706/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6486706/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":93055885,"identity":"84d7aa51-596e-4c6e-9668-3d6c35088b34","added_by":"auto","created_at":"2025-10-08 14:55:12","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2309430,"visible":true,"origin":"","legend":"Article File","description":"","filename":"Imagingofartificialtumorpaper.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6486706/v1_covered_62fd67d6-6447-47df-989a-c0493a507eda.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"Imaging of artificial tumor models in an anatomical breast phantom with a single-sided magnetic particle imaging scanner","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"MPI, breast cancer, imaging, nanoparticles","lastPublishedDoi":"10.21203/rs.3.rs-6486706/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6486706/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Magnetic Particle Imaging (MPI) is an emerging biomedical imaging modality that detects superparamagnetic iron oxide (SPIO) nanoparticle tracers, providing high contrast, sensitivity, and quantification capabilities without the use of ionizing radiation, making it particularly suitable for cancer diagnostics. 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