Estrogen Receptor Gene Polymorphisms and Endometriosis

Endometriosis is an estrogen-dependent disease.Estrogen regulates the expression of several genes in combination with its receptor (ER),thus playing an important physiological action.As a result,the change in ER may affect the biological effect of estrogen.Recent studies suggest that ER gene polymorphisms has an association with the risk of endometriosis,which is of significant to reveal the development,diagnosis,therapeutics and prognosis of endometriosis.This review summarizes current studies on correlation between ER gene polymorphisms and endometriosis.