Software-based Data Processing Methods for Uranium Isotope Measurements by a Self-developed Multi-collector Mass Spectrometry

Software-based Data Processing Methods for Uranium Isotope Measurements by a Self-developed Multi-collector Mass Spectrometry | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Software-based Data Processing Methods for Uranium Isotope Measurements by a Self-developed Multi-collector Mass Spectrometry Yurong Li, Jing Wu, Zhiqiang Wang, Li Li, Yufei Zhao, Yongquan Qin, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8846604/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Multi-collector thermal ionization mass spectrometry (TIMS) is widely used for high-precision uranium isotope ratio measurements in nuclear material analysis. In this work, a self-built TIMS system (TIMS-II) and its dedicated measurement software were developed with emphasis on software-oriented data processing and correction methods. Algorithms for peak center identification, software-controlled background evaluation, mass-dependent fractionation correction, and inter-Faraday cup efficiency correction were implemented and integrated into a unified measurement workflow. The performance of the developed system and software was evaluated through uranium isotope measurements using natural uranium and the CRM U500 standard solution. Repeated measurements demonstrate stable and reproducible results, and the corrected 235 U/ 238 U isotope ratios obtained for CRM U500 agree with the certified value within its stated uncertainty. The results indicate that the proposed software-based data processing framework provides a practical and reliable approach for uranium isotope analysis using self-built TIMS systems. Thermal ionization mass spectrometry Uranium isotope measurement Data processing software Peak identification Faraday cup correction Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8846604","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":599989542,"identity":"1a194615-39d9-48ce-9992-304905d99a30","order_by":0,"name":"Yurong Li","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Yurong","middleName":"","lastName":"Li","suffix":""},{"id":599989547,"identity":"0736d947-e9a7-481d-924c-981db8ae6377","order_by":1,"name":"Jing Wu","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Jing","middleName":"","lastName":"Wu","suffix":""},{"id":599989552,"identity":"48c76a5d-759f-4673-ad38-1989d13deaba","order_by":2,"name":"Zhiqiang Wang","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Zhiqiang","middleName":"","lastName":"Wang","suffix":""},{"id":599989553,"identity":"a7b5bc39-5c07-430d-82c6-840d360b640b","order_by":3,"name":"Li Li","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Li","middleName":"","lastName":"Li","suffix":""},{"id":599989554,"identity":"e4370fbe-2451-47a4-a844-3e9f61888cc6","order_by":4,"name":"Yufei Zhao","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Yufei","middleName":"","lastName":"Zhao","suffix":""},{"id":599989555,"identity":"12f1bce8-6f2e-4984-a1ee-87a5fcc72ef9","order_by":5,"name":"Yongquan Qin","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Yongquan","middleName":"","lastName":"Qin","suffix":""},{"id":599989556,"identity":"c163e81e-6f40-46ea-a101-f4ec43a49c33","order_by":6,"name":"Yantao Hu","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Yantao","middleName":"","lastName":"Hu","suffix":""},{"id":599989558,"identity":"6f2bc1ce-2bf9-482f-a2fe-54eae54d3e28","order_by":7,"name":"Jing Ma","email":"","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":false,"prefix":"","firstName":"Jing","middleName":"","lastName":"Ma","suffix":""},{"id":599989561,"identity":"ee9f1a5c-9589-48ed-b98f-6977995637e8","order_by":8,"name":"Quanwei Liu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4ElEQVRIiWNgGAWjYBACPijNY3+8+QCQlpAhqIUNpoXhzLEEkBYeorUwMNzIMYDoJaiFPcfwc2GbjQxjQ87nVzdqLHgY2A8f3YBXC88bY+mZbWk8zAxnt1nnHAM6jCct7QZeLRI5BtK82w7zsDH2bjPOYQNqkeAxI6TF+Dfvtv88PMw8z4xz/hGnxQxoywEeCTYe5se5bcRo4XlWZs37L5nHgIfNjDm3T4KHjZBf+NmTN9/mOWNnbyD/+PHnnG91cvzsh4/h1cLAkIDkSDCJXzmqFuYPhFWPglEwCkbBSAQAKfI9g9Z6WGEAAAAASUVORK5CYII=","orcid":"","institution":"China Nuclear Power Engineering Co.","correspondingAuthor":true,"prefix":"","firstName":"Quanwei","middleName":"","lastName":"Liu","suffix":""}],"badges":[],"createdAt":"2026-02-11 03:24:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8846604/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8846604/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":104402324,"identity":"7a497a4b-763c-4383-a79f-526977d5921a","added_by":"auto","created_at":"2026-03-11 12:15:03","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":521030,"visible":true,"origin":"","legend":"","description":"","filename":"SoftwarebasedDataProcessingMethodsforUraniumIsotopeMeasurementsbyaSelfbuiltTIMS1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8846604/v1_covered_84674027-de85-448d-873c-99b1b9bf2dc9.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Software-based Data Processing Methods for Uranium Isotope Measurements by a Self-developed Multi-collector Mass Spectrometry","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Thermal ionization mass spectrometry, Uranium isotope measurement, Data processing software, Peak identification, Faraday cup correction","lastPublishedDoi":"10.21203/rs.3.rs-8846604/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8846604/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eMulti-collector thermal ionization mass spectrometry (TIMS) is widely used for high-precision uranium isotope ratio measurements in nuclear material analysis. In this work, a self-built TIMS system (TIMS-II) and its dedicated measurement software were developed with emphasis on software-oriented data processing and correction methods. Algorithms for peak center identification, software-controlled background evaluation, mass-dependent fractionation correction, and inter-Faraday cup efficiency correction were implemented and integrated into a unified measurement workflow. The performance of the developed system and software was evaluated through uranium isotope measurements using natural uranium and the CRM U500 standard solution. Repeated measurements demonstrate stable and reproducible results, and the corrected \u003csup\u003e235\u003c/sup\u003eU/\u003csup\u003e238\u003c/sup\u003eU isotope ratios obtained for CRM U500 agree with the certified value within its stated uncertainty. The results indicate that the proposed software-based data processing framework provides a practical and reliable approach for uranium isotope analysis using self-built TIMS systems.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e","manuscriptTitle":"Software-based Data Processing Methods for Uranium Isotope Measurements by a Self-developed Multi-collector Mass Spectrometry","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-03-05 12:13:31","doi":"10.21203/rs.3.rs-8846604/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"3fa95a82-5340-48fa-a8d6-e0293ecbe25f","owner":[],"postedDate":"March 5th, 2026","published":true,"recentEditorialEvents":[{"type":"decision","content":"Revision requested","date":"2026-05-13T08:26:02+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-12T13:56:35+00:00","index":35,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-10T10:14:03+00:00","index":34,"fulltext":""}],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-05-13T08:43:25+00:00","versionOfRecord":[],"versionCreatedAt":"2026-03-05 12:13:31","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8846604","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8846604","identity":"rs-8846604","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}