Nanomedicine Applications in Lymphoma: Advancing Precision Diagnostics, Targeted Therapeutics, and Prospective Developments

Nanomedicine Applications in Lymphoma: Advancing Precision Diagnostics, Targeted Therapeutics, and Prospective Developments | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 24 February 2026 V1 Latest version Share on Nanomedicine Applications in Lymphoma: Advancing Precision Diagnostics, Targeted Therapeutics, and Prospective Developments Authors : Ahmar Rauf 0000-0001-5639-2208 , Yara Mashal , Afeefa Rao , Nasar Ata , Farhan Shah [email protected] , and Arun Iyer 0000-0002-4428-0222 Authors Info & Affiliations https://doi.org/10.22541/au.177194185.50088759/v1 147 views 90 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Lymphomas represent a diverse array of B- and T-cell malignancies, where obstacles such as drug resistance, treatment-related toxicity, and disease heterogeneity continue to hinder cure rates, even with advancements in immunotherapy and targeted therapies. Nanomedicine offers potential solutions to these challenges by enhancing tumor-selective delivery, enabling real-time disease monitoring, and facilitating strategic combination therapy. Liposomes, gold nanoparticles, and polymeric nanocarriers improve lymphoma-specific accumulation of chemotherapeutics and biologics, counteract efflux-mediated chemoresistance, and minimize off-target exposure to these agents. Simultaneously, quantum dots, plasmonic gold nanostructures, and superparamagnetic iron oxide nanoparticles have enhanced diagnostic capabilities for highly sensitive fluorescence, optical, and MRI-based detection and separation of malignant lymphocytes, paving the way for multifunctional theranostic platforms for leukemia. Innovative strategies include pretargeted two-step nanoparticle systems for precise tumor ablation, mRNA-loaded nanoparticles for in situ vaccination using immune-stimulatory cytokines, and non-viral lipid nanoparticle technologies for in vivo CAR T engineering and CRISPR-mediated genome editing of lymphoma or stromal cells to modify the tumor microenvironment. Artificial intelligence is increasingly being used to optimize nanoparticle composition and targeting, accelerating the development of personalized nanomedicines tailored to the molecular and microenvironmental characteristics of individual lymphomas. These advancements collectively contribute to integrated nanotheranostic techniques that enhance diagnostic precision, facilitate accurate image-guided interventions, and promote safer, more effective, and tailored therapeutic approaches for patients with lymphoma. Supplementary Material File (lymphoma review- 02052026.docx) Download 6.40 MB Information & Authors Information Version history V1 Version 1 24 February 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords diagnostics gene therapy lymphoma nanomedicine targeted delivery Authors Affiliations Ahmar Rauf 0000-0001-5639-2208 Wayne State University View all articles by this author Yara Mashal University of Michigan View all articles by this author Afeefa Rao Jamia Hamdard University View all articles by this author Nasar Ata Henry Ford Health System View all articles by this author Farhan Shah [email protected] Umea universitet Medicinska fakulteten View all articles by this author Arun Iyer 0000-0002-4428-0222 Wayne State University View all articles by this author Metrics & Citations Metrics Article Usage 147 views 90 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Ahmar Rauf, Yara Mashal, Afeefa Rao, et al. Nanomedicine Applications in Lymphoma: Advancing Precision Diagnostics, Targeted Therapeutics, and Prospective Developments. Authorea . 24 February 2026. DOI: https://doi.org/10.22541/au.177194185.50088759/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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