Nanoparticle-in-Microparticle Oral Delivery System Based on Drug-Loaded Polymeric Micelles

Abstract This work develops and characterises a hierachichal oral drug delivery system based on the microencapsulation of drug-loaded amphiphilic nanogels within a mucoadhesive alginate/chitosan shell. Results show a more controlled release and a statistically significant oral half-life with respect to the free drug. Competing Interest Statement The authors have declared no competing interest. Footnotes A typo in the abstract has been corrected Funder Information Declared Uzi & Michal Halevy Fund for Innovative Applied Engineering Research Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.