A Deterministic Modeling Approach in Identifying the Optimal Screening for Human Immunodeficiency Virus Management

A Deterministic Modeling Approach in Identifying the Optimal Screening for Human Immunodeficiency Virus Management | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A Deterministic Modeling Approach in Identifying the Optimal Screening for Human Immunodeficiency Virus Management Adeniyi Oyewole Ogunmola, Emmanuel Tejuola Jolayemi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4618889/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The enormous success made in the development of drugs for Human Immunodeficiency Virus (HIV) infection to suppress the viral load of the disease, avert death and suffering due to the disease, no HIV individual is supposed to experience morbidity or death due to the disease. However, most affected people only avail themselves for HIV test at symptomatic stage which leads to morbidity and mortality due to Acquired Immune Deficiency Syndrome (AIDS). In the absence of HIV vaccine for the prevention against HIV infection, HIV screening test would be the next close to vaccination. This aim of this study was to developed a model that determine the optimal HIV screening sequence as intervention for HIV in a population. The concept of screening was brought into system of non-linear differential equations to obtain the deterministic model. The screening sequence and the varying population proportions were used in determining the optimal screening. The findings were that; when the systematic HIV screening of the population was done in six years, mortality and morbidity occurrences were reduced, and subsequent systematic screening reduced morbidity and mortality more in the population; and screening thirty percent of the population every year saved the lives of ninety percent HIV individuals and forestalled ninety percent of them from experiencing morbidity. It was noted also that screening fifty percent of the population three times within six years produced the same effect. HIV/AIDS deterministic modeling systematic screening morbidity and mortality Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4618889","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":334328423,"identity":"ce7ff6eb-4843-4e28-9a8d-2b189fd1df4a","order_by":0,"name":"Adeniyi Oyewole Ogunmola","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA/UlEQVRIiWNgGAWjYPACCwZ+5gNAGojZgJQEEVokGCTbEkjVYnAMqoWBkBZ+/jVmj25USMgbH+Mxk+Y5Y5fPx8B88DYPwx27BhxaJGe8MTfOOSNhuA2s5UayZRsDW7I1D8OzZFxaDG6cMZPObZNg3Ha/x+w2zwdmAzYGkF6Gw8m4HAbTYr+5jQekpR6ohf8bfi3ne8BaEjewgbTcOAyyhQ2kxQ6XFskZbGXSQL8kzzjGVv5zzpnjBmzMbMaWcwwOJ+DSws9/eJt0ToWNbX8b82aDN8eqDeTbmx/eeFNx2B6XFgYJDNOYwQ5mSGzAac0BHBK4bRkFo2AUjIKRBgDnZE6dIKQPGQAAAABJRU5ErkJggg==","orcid":"","institution":"Federal University Wukari","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Adeniyi","middleName":"Oyewole","lastName":"Ogunmola","suffix":""},{"id":334328425,"identity":"68f1f3df-3d7f-40a4-bb12-98447689237b","order_by":1,"name":"Emmanuel Tejuola Jolayemi","email":"","orcid":"","institution":"University of Ilorin","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Emmanuel","middleName":"Tejuola","lastName":"Jolayemi","suffix":""}],"badges":[],"createdAt":"2024-06-21 18:14:12","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4618889/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4618889/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":66677695,"identity":"ed425fc3-9936-4161-ab6e-34137e0af394","added_by":"auto","created_at":"2024-10-15 11:31:51","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":393745,"visible":true,"origin":"","legend":"","description":"","filename":"OptimalScreeningforHIVManagement1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4618889/v1_covered_ff319a30-c841-4694-9419-c5d4b96bbda2.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eA Deterministic Modeling Approach in Identifying the Optimal Screening for Human Immunodeficiency Virus Management\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"HIV/AIDS, deterministic modeling, systematic screening, morbidity and mortality","lastPublishedDoi":"10.21203/rs.3.rs-4618889/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4618889/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe enormous success made in the development of drugs for Human Immunodeficiency Virus (HIV) infection to suppress the viral load of the disease, avert death and suffering due to the disease, no HIV individual is supposed to experience morbidity or death due to the disease. 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