AlgMA/HAMA self-healing bioinks with β-cyclodextrin and Adamantane modified IPN structure for Tissue Engineering

AlgMA/HAMA self-healing bioinks with β-cyclodextrin and Adamantane modified IPN structure for Tissue Engineering | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article AlgMA/HAMA self-healing bioinks with β-cyclodextrin and Adamantane modified IPN structure for Tissue Engineering Elif Yüce, Burçin İzbudak, Banu Kocaağa, Seniha F. Güner, Ayça Bal Öztürk, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7462932/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 11 You are reading this latest preprint version Abstract Three-dimensional (3D) bioprinting has revolutionized the field of tissue engineering by enabling the fabrication of complex biological structures with high precision. The development of bioinks with enhanced mechanical, rheological, and biological properties is critical for advancing this technology. In this study, we designed biocompatible bioinks with self-healing capabilities using host-guest molecules modified onto two distinct polymeric networks. To achieve this, two different polymer chains were utilized: one was functionalized with a host molecule (β-cyclodextrin) and the other with a guest molecule (1-adamantane acetic acid). Alginate methacrylate (AlgMa) was synthesized and subsequently modified with the host molecule, while hyaluronic acid was methacrylated and then modified with the guest molecule. Consequently, host-guest interaction-based biominks with interpenetrating polymer network (IPN) structures were prepared, leading to the development of these advanced bioinks.The resulting interpenetrating polymer network (IPN) structures exhibited improved mechanical stability, as demonstrated by oscillation frequency sweep tests. Our bioinks demonstrated excellent shear-thinning behavior, facilitating printability and maintaining shape fidelity during and after the bioprinting process. These features make them highly suitable for use in tissue scaffold fabrication. By leveraging the unique properties of self-healing bioinks, we provide a significant contribution to the development of durable, functional materials for tissue engineering applications. bioinks host-guest interactions IPN structure self-healing properties Full Text Additional Declarations No competing interests reported. Supplementary Files graphicalabstract.png Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 02 Dec, 2025 Reviews received at journal 23 Nov, 2025 Reviews received at journal 12 Nov, 2025 Reviews received at journal 11 Nov, 2025 Reviewers agreed at journal 10 Nov, 2025 Reviewers agreed at journal 08 Nov, 2025 Reviewers agreed at journal 08 Nov, 2025 Reviewers invited by journal 16 Sep, 2025 Editor assigned by journal 05 Sep, 2025 Submission checks completed at journal 05 Sep, 2025 First submitted to journal 26 Aug, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7462932","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":517024163,"identity":"df3cad4a-f50c-473f-8b2e-6d9ee0d4718c","order_by":0,"name":"Elif Yüce","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3klEQVRIiWNgGAWjYDACdsaGDxBGA5hibCCohZmxcQaYwXMYpoWZkBYGRogWiWQitfAzMzc2MLYdlueXfH/wMw+DjeyGA/zHPuDTItnMCNZiOHN2MrM0D0Oa8YYDzMwz8GkxOMzY/gCoJcHgdjIDUMvhRJAWvA6zPwyxJcH+5mHm3zwM/wlrMWCGajGQYGYD2nKAsBYJkC0J59INZ5xJNrOcY5BsPPMwszFeLfzt7Q8bPpRZy/O3H3x8402FnWzf8cbHeLWAQSIb3J0MDARjEgL+EKVqFIyCUTAKRioAACQ8RKddCiCKAAAAAElFTkSuQmCC","orcid":"","institution":"Istanbul University-Cerrahpaşa","correspondingAuthor":true,"prefix":"","firstName":"Elif","middleName":"","lastName":"Yüce","suffix":""},{"id":517024164,"identity":"0619249f-7978-4bf1-b36f-407baca26041","order_by":1,"name":"Burçin İzbudak","email":"","orcid":"","institution":"Istinye University","correspondingAuthor":false,"prefix":"","firstName":"Burçin","middleName":"","lastName":"İzbudak","suffix":""},{"id":517024165,"identity":"fe7c3572-21f5-42f4-ac55-8a543652df9b","order_by":2,"name":"Banu Kocaağa","email":"","orcid":"","institution":"Istanbul Technical University","correspondingAuthor":false,"prefix":"","firstName":"Banu","middleName":"","lastName":"Kocaağa","suffix":""},{"id":517024166,"identity":"e0cd7e89-4f07-41df-9f7c-70493951c490","order_by":3,"name":"Seniha F. 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