Penile Prosthesis Implantation as First-Line Surgery in Peyronie’s Disease with or without ED

Abstract Penile prosthesis (PP) in Peyronie’s disease (PD) is considered only when pharmacotherapy has failed in management of erectile dysfunction (ED). Patients with PD who underwent PP (malleable or inflatable) with or without additional maneuvers like manual modeling and grafting from 2012 to 2022 were included in the study. Patient and partner satisfaction were assessed using a 5-point Likert scale. ED was assessed using a validated questionnaire. A total of 168/636 patients underwent PP as first-line surgical management for PD and were included in the study. The mean age was 56.3 years +/- 12.4 and a median BMI of 27.2. Mean follow-up was 56 months (95% CI: 11-21). All 168 patients had undergone additional maneuvers such as manual modeling in 85.7% and grafting in 14.3%. Majority of the patients underwent a 3-piece inflatable PP (86.9%). Thirty-three (19.7%) PD patients without ED had undergone PP. The satisfaction of PD patients with ED and without ED was not statistically different (88.9% vs 87.9%). If surgery is offered in PD, PP may be considered as a first-line surgical treatment regardless of the ED in view of the acceptable complications and high satisfaction rates.