Extending the use of gonadotropin-releasing hormone agonists: the emerging role of steroidal and nonsteroidal agents

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This review analyzes the current literature on long-term GnRH agonist use and suggests further studies are needed to understand optimal sex steroid add-back therapy.

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Abstract

OBJECTIVE: To review and summarize the state of the art as it relates to the long-term application of GnRH agonists (GnRH-a). DESIGN: A retrospective analysis of the available literature and results and an up-to-date review of a rapidly evolving field. CONCLUSION: Although the precise use of long-term GnRH-a therapy (in conjunction with sex steroid add-back therapy) remains unknown, the information provided strongly supports additional studies in this area to achieve a body of promising preliminary data.

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Condition tags

endometriosis

MeSH descriptors

Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Endometriosis Endometriosis Endometriosis Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Humans Leiomyoma Leiomyoma Leiomyoma Menstruation Disturbances Menstruation Disturbances Menstruation Disturbances Ovary Ovary

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Source provenance

europepmc
last seen: 2026-10-04T09:26:46.659050+00:00
pubmed
last seen: 2026-10-08T21:59:25.815134+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
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