Editorial: Searching for causes of infertility: from pathophysiologic mechanisms to therapeutic strategies

Marzena Kamieniczna, Marta Olszewska, Agnieszka Malcher, Tomasz Stokowy, Sezgin Gunes
Frontiers in genetics · 2024 · vol. 15 , pp. 1432026 · doi:10.3389/fgene.2024.1432026 · PMID:38988834 · PMC11233803
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-13 ⓘ

This editorial collection highlights research on reproductive disorders, identifying genetic variants associated with cervical cancer, ovarian endometriosis, premature ovarian insufficiency, and offspring health impacts from maternal hyperhomocysteinemia.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This editorial surveys the genetic and mechanistic research on causes of infertility, highlighting how advanced genomic approaches and animal models are used to study fertilization and reproductive disorders, with the key emphasis that genetic factors may refine diagnosis and therapeutic strategies; it explicitly presents itself as a curated collection rather than a single original study. It summarizes multiple featured papers across conditions including cervical cancer, male spermatogenic failure, premature ovarian insufficiency, and offspring effects of maternal hyperhomocysteinemia, and it notes specific genetic findings such as WTAP variants associated with ovarian endometriosis risk in Chinese women, alongside other gene polymorphisms and mutations in different reproductive diseases. A caveat is that the piece is an editorial overview that points readers to selected publications and does not provide new experimental results or pooled analyses itself. Relevance to endometriosis: the editorial explicitly includes and describes a study by Wan et al. reporting associations between WTAP gene polymorphisms and ovarian endometriosis risk, though its main focus is broadly on searching for infertility causes across multiple reproductive disorders.

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References

1 CausinR. L.FreitasA. J. A.Trovo Hidalgo FilhoC. M.ReisR. D.ReisR. M.MarquesM. M. C. (2021). A systematic review of MicroRNAs involved in cervical cancer progression. Cells10 (3), 668. 10.3390/cells10030668 2 HillyarC. R.KanabarS. S.PufalK. R.Saw HeeJ. L.LawsonA. W.MohamedY.et al (2023). A systematic review and meta-analysis of miRNAs for the detection of cervical cancer. Epigenomics15 (10), 593–613. 10.2217/epi-2023-0183 3 KinaB. G.Topbas SelcukiN. F.BahatP. Y.UstaT.AydinS.RahmiogluN.et al (2024). Whole exome sequencing reveals novel candidate variants for endometriosis utilizing multiple affected members in a single family. Mol. Genet. Genomic Med.12 (1), e2312. 10.1002/mgg3.2312 4 LinderA.Westbom-FremerS.MateoiuC.OlssonW. A.ÖsterlundT.VeerlaS.et al (2024). Genomic alterations in ovarian endometriosis and subsequently diagnosed ovarian carcinoma. Hum. Reprod.39 (5), 1141–1154. 10.1093/humrep/deae043 5 MalcherA.StokowyT.BermanA.OlszewskaM.JedrzejczakP.SielskiD.et al (2022). Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia. Andrology10 (8), 1605–1624. 10.1111/andr.13269 6 NagirnajaL.LopesA. M.CharngW. L.MillerB.StakaitisR.GolubickaiteI.et al (2022). Diverse monogenic subforms of human spermatogenic failure. Nat. Commun.13 (1), 7953. 10.1038/s41467-022-35661-z 7 ShenS.ZhangS.LiuP.WangJ.DuH. (2020). Potential role of microRNAs in the treatment and diagnosis of cervical cancer. Cancer Genet.248-249, 25–30. 10.1016/j.cancergen.2020.09.003 8 TurkyilmazA.AlavandaC.AtesE. A.GeckinliB. B.PolatH.GokcuM.et al (2022). Whole-exome sequencing reveals new potential genes and variants in patients with premature ovarian insufficiency. J. Assist. Reprod. Genet.39 (3), 695–710. 10.1007/s10815-022-02408-0 Summary

Keywords

microRNA, cervical cancer, premature ovarian insufficiency, hyperhomocysteinemia, sleep traits, genome, infertility, endometriosis Citation Kamieniczna M, Olszewska M, Malcher A, Stokowy T and Gunes S (2024) Editorial: Searching for causes of infertility: from pathophysiologic mechanisms to therapeutic strategies. Front. Genet. 15:1432026. doi: 10.3389/fgene.2024.1432026 Received 13 May 2024 Accepted 14 June 2024 Published 26 June 2024 Volume 15 - 2024 Edited and reviewed by Masood Bazrgar, Royan Institute, Iran Updates Copyright © 2024 Kamieniczna, Olszewska, Malcher, Stokowy and Gunes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: Marzena Kamieniczna, [email protected]; Marta Olszewska, [email protected]; Agnieszka Malcher, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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