KDM3A silencing effectively inhibits bone turnover and metastasis development in breast cancer

Objective: Bone metastasis is the main cause of death in patients with breast cancer (BCa). Lysine demethylase 3A (KDM3A) plays an important role in metastatic breast cancer. In our study, we aimed to detect the expression and invasion of KDM3A in bone metastases from breast cancer, and provide an important theoretical basis for effective prevention and treatment of BCa. Methods: : MDA-MB-231 breast cancer cells were transfected with KDM3A shRNA lentivirus to knock down KDM3A level. The biological function of KDM3A was examined in MDA-MB-231 breast cancer cells, MCF-10A breast epithelial cells and nude mice with bone metastasis. Results: : Silencing KDM3A significantly inhibited the proliferation, metastasis and invasion of BCa cells and promoted apoptosis in both in vivo and in vitro experiments. Conclusion: siRNA-mediated silencing of KDM3A can inhibit the proliferation, invasion and promote apoptosis of BCa cells.