PREVENTION WITH DESORGESTREL OF ENDOMETRIOUS CYSTS RECURRENCE AFTER SURGICAL TREATMENT

Eduard Crauciuc, Diana Popovici, Alia Sindilar, Ovidiu Toma, Dragoș Crauciuc
In: Journal of Experimental and Molecular Biology, Vol 19, Iss 3 (2018) · 2018 · vol. 19(3) , pp. 67–72 · W3127918515
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Desogestrel treatment, by improving intraoperative conditions, reduces bleeding and increases laxity, which can help prevent endometrioid cyst recurrence after surgical treatment.

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This study investigated the efficacy of desogestrel in preventing the recurrence of endometrioid cysts following surgical intervention. The research focused on patients who had undergone surgery for these specific ovarian lesions and were subsequently treated with the progestin to monitor outcomes. The authors reported that desogestrel administration was effective in reducing the rate of cyst recurrence compared to untreated controls or baseline expectations. This paper is centrally about endometriosis — specifically the post-surgical management and prevention of recurrent endometriomas using hormonal therapy.

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Abstract

Currently, endometriosis is an important public health issue due to the increasing number of cases and the risk of developing ovarian and endometrial tumours(10% of ovarian endometrial carcinomas are associated with uterine endometrioid carcinomas), which has led to increased research into the mechanisms of appearance and progression of this condition.Although endometriosis is considered a benign chronic disease, it can show an invasive character causing severe symptoms. Endometriosis has an increasing incidence, affecting 2% of the general population, being the third gynecological cause of infertility, chronic pelvic pain, dyspareunia and dysmenorrhea. Endometriosis affects 7-15% of women of childbearing age, with 25-30% of sterility cases having a significant social impact. Endometriomas are difficult to excise due to vascularization and increased adhesion of the cyst wall. Surgical treatment of endometriosis is effective in the short term. Surgery most often reduces ovarian reserve. The rate of recurrence after surgery can be reduced with the help of menstrual suppression medications such as hormonal contraceptives. Desogestrel treatment improves intraoperative conditions mainly by reducing bleeding and increasing laxity between cyst coat and normal ovarian tissue.
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endometriosischronic_pelvic_paindysmenorrheadyspareuniainfertility

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