Celiac disease and endometriosis: an insidious and worrisome association hard to diagnose: a case report

Donatella Caserta, Elena Matteucci, E. Ralli, Giulia Bordi, Massimo Moscarini
In: Clinical and Experimental Obstetrics & Gynecology · 2014 · vol. 41(3) , pp. 346–348 · doi:10.12891/ceog16842014 · W285703500
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This case report describes a patient with primary infertility, endometriosis, and delayed celiac disease diagnosis who achieved a favorable response to a gluten-free diet and a successful pregnancy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This case report describes a 34-year-old woman with primary infertility whose prior evaluation and treatment focused on endometriosis, while her celiac disease (CD) diagnosis was delayed because of non-classical features. The authors report that after starting a gluten-free diet (GFD), the patient achieved a favorable clinical and serological response, and she subsequently obtained a successful pregnancy. The paper’s main limitation is that it is a single-patient case and does not establish the nature or strength of an association between CD and endometriosis. This paper is centrally about endometriosis — it presents a diagnostic challenge and delayed CD diagnosis in a woman previously treated for endometriosis.

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Abstract

Background: Primary infertility is an unusual presentation of celiac disease (CD). When non-classical symptoms are present, the diagnosis is not easy and it becomes even more difficult when CD is associated with endometriosis, representing a diagnostic challenge for medical practitioners and gynecologists. Case Report: A 34-year-old patient presented to the authors’ observation with primary infertility. Formerly she was treated for endometriosis and the diagnosis of CD was delayed. A favorable clinical and serological response following a gluten-free-diet (GFD) was achieved and a successful pregnancy was obtained. Discussion: This case report emphasizes the role of the CD in women’s infertility and the possible association between CD and endometriosis. Even if the relationship between these two diseases is still unclear and further studies to address this issue are required, more attention from gynecologists is needed, considering that the later this association is diagnosed, the greater the probability of adverse outcomes of health developing.
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Abstract

Background: Primary infertility is an unusual presentation of celiac disease (CD). When non-classical symptoms are present, the diagnosis is not easy and it becomes even more difficult when CD is associated with endometriosis, representing a diagnostic challenge for medical practitioners and gynecologists. Case Report: A 34-year-old patient presented to the authors’ observation with primary infertility. Formerly she was treated for endometriosis and the diagnosis of CD was delayed. A favorable clinical and serological response following a gluten-free-diet (GFD) was achieved and a successful pregnancy was obtained. Discussion: This case report emphasizes the role of the CD in women’s infertility and the possible association between CD and endometriosis. Even if the relationship between these two diseases is still unclear and further studies to address this issue are required, more attention from gynecologists is needed, considering that the later this association is diagnosed, the greater the probability of adverse outcomes of health developing.

Keywords

- Celiac disease - Endometriosis - Infertility - Pregnancy - Gluten-free-diet

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Condition tags

endometriosisinfertility

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