Variety of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor KDR expression and microvessels density in endometrium before and after transcervical resection of endometrium

Objective: To evaluate the molecular mechanism of Transcervical Resection of Endometrium (TCRE) surgery on patient with adenomyosis. Methods: There were 21 cases of TCRE for adenomyosis from October 2000 to November 2002. Using immunohistochemistry (LSAB) on endometrial sections, ten adenomyosis endometrium before TCRE, seven adenomyosis endometrium after TCRE, eight normal controls. The VEGF, KDR staining indices were determined with an computerized image analyzer. Results: The MVD, VEGF and KDR staining indices were significantly lower in adenomyosis after the surgery than in normal endometrium and before the surgery (P0.05), just same as that of the control. One case of adenomyosis endometrium having second TCRE had high-score of VEGF, KDR expression and MVD. Conclusions: TCRE have lowed significantly the score of KDR, VEGF and MVD expression of the endometrium with adenomysis, the lower-score of MVD, VEGF and KDR may be related to the prognosis of TCRE.