Immunocytochemical analysis of proliferative activity of endometrial and myometrial cell populations in focal and stromal adenomyosis

L M Nepomnyashchikh, E L Lushnikova, O P Molodykh, A K Pichigina
Bulletin of experimental biology and medicine · 2013 · doi:10.1007/s10517-013-2190-5 · PMID:24143380
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Ki-67 revealed differential proliferative activity in endometrial and myometrial cells across adenomyosis subtypes, with focal adenomyosis showing higher epithelial proliferation and stromal adenomyosis higher stromal cell proliferation.

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This immunocytochemical study assessed proliferative activity by detecting the Ki-67 antigen across endometrial and myometrial cell populations in focal versus stromal (diffuse) adenomyosis, comparing eutopic “normal” endometrium with ectopic glandular and stromal components. Ki-67 was present in multiple adenomyosis cell types, including endometrial and myometrial glandular epithelium, stromal cells, smooth muscle cells, and vascular endotheliocytes, with labeled indices differing by cell population. The highest labeled index occurred in endometrial gland epitheliocytes in focal adenomyosis (23.2±2.9%), while stromal adenomyosis showed about 2.8-fold lower values in gland epitheliocytes despite frequent association with glandular hyperplasia; secretory epitheliocytes had lower proliferative activity than normal eutopic endometrium. Relevance to endometriosis: Although the paper focuses on adenomyosis, it analyzes the proliferative behavior of ectopic endometrial-like cell populations within the myometrium, which is directly pertinent to endometriosis-related mechanisms of aberrant endometrial tissue proliferation.

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Abstract

Immunocytochemical study has shown that Ki-67 antigen is detected in adenomyosis in both endometrial and myometrial cell populations (in the eutopic and ectopic endometrial glandular epithelium, stromal cells, smooth muscle cells, and vascular endotheliocytes of the endometrium and myometrium), the label index differing significantly in different cell populations. The highest labeled cell index is found in the endometrial gland epitheliocytes in focal adenomyosis (23.2 ± 2.9%); in the stromal variant this index is by 2.8 times lower despite the fact that this variant is associated with endometrial glandular hyperplasia in the majority of cases. Proliferative activity of secretory epitheliocytes is significantly lower in both adenomyosis variants than in the normal eutopic endometrium. Stromal adenomyosis is characterized by 2-fold higher proliferative activity of the cytogenic stroma than that in focal adenomyosis.
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Immunocytochemical study has shown that Ki-67 antigen is detected in adenomyosis in both endometrial and myometrial cell populations (in the eutopic and ectopic endometrial glandular epithelium, stromal cells, smooth muscle cells, and vascular endotheliocytes of the endometrium and myometrium), the label index differing significantly in different cell populations. The highest labeled cell index is found in the endometrial gland epitheliocytes in focal adenomyosis (23.2±2.9%); in the stromal variant this index is by 2.8 times lower despite the fact that this variant is associated with endometrial glandular hyperplasia in the majority of cases. Proliferative activity of secretory epitheliocytes is significantly lower in both adenomyosis variants than in the normal eutopic endometrium. Stromal adenomyosis is characterized by 2-fold higher proliferative activity of the cytogenic stroma than that in focal adenomyosis. Similar content being viewed by others References N. M. Anichkov and V. A. Pechenikova, Arkh. Patol., No. 3, 31–34 (2005). N. M. Anichkov, V. A. Pechenikova, and D. F. Kostyuchek, Arkh. Patol., No. 4, 5–10 (2011). O. V. Zairatyants, L. V. Adamyan, E. N. Andreeva, et al., Arkh. Patol., No. 5, 6–12 (2010). O. V. Zairatyants, L. V. Adamyan, M. M. Sonova, et al., Arkh. Patol., No. 5, 16–19 (2008). E. A. Kogan, A. L. Unanyan, T. A. Demura, et al., Arkh. Patol., No. 5, 8–12 (2008). L. M. Nepomnyashchikh, E. L. Lushnikova, O. G. Pekarev, et al., Bull. Exp. Biol. Med., 153, No. 1, 109–113 (2012). L. M. Nepomnyashchikh, E. L. Lushnikova, O. G. Pekarev, et al., Sib. Onkol. Zh., No. 2, 39–44 (2012). S. V. Pavlovich, N. I. Volkov, and V. A. Burlev, Bull. Exp. Biol. Med., 136, No. 4, 396–398 (2003). A. L. Unanyan, I. S. Sidorova, and E. A. Kogan, Akush. Ginekol. Reprod., No. 2, 25–30 (2012). A. Arici, Ann. NY Acad. Sci., 955, 101–109 (2002). A. Hever, R. B. Roth, P. A. Hevezi, et al., Mol. Hum. Reprod., 12, No. 12, 737–748 (2006). J. Q. Huang, R. B. Lathi, M. Lemyre, et al., Fertil. Steril., 94, No. 2, 720–723 (2010). M. S. Khan, A. R. Dodson, and M. K. Heatley, J. Clin. Pathol., 52, No. 7, 517–520 (1999). F. A. Taran, A. L. Weaver, C. C. Coddington, and E. A. Stewart, Hum. Reprod., 25, No. 5, 1177–1182 (2010). A. Vodolazkaia, Y. El-Aalamat, D. Popovic, et al., Hum. Reprod., 27, No. 9, 2698–2711 (2012). Author information Authors and Affiliations Corresponding author Additional information Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 4, pp. 511-516, April, 2013 Rights and permissions About this article Cite this article Nepomnyashchikh, L.M., Lushnikova, E.L., Molodykh, O.P. et al. Immunocytochemical Analysis of Proliferative Activity of Endometrial and Myometrial Cell Populations in Focal and Stromal Adenomyosis. Bull Exp Biol Med 155, 512–517 (2013). https://doi.org/10.1007/s10517-013-2190-5 Received: Published: Issue date: DOI: https://doi.org/10.1007/s10517-013-2190-5

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endometriosisadenomyosis

MeSH descriptors

Adenomyosis Cell Proliferation Endometrium Myometrium Adenomyosis Adenomyosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Immunohistochemistry Ki-67 Antigen Ki-67 Antigen Middle Aged Myocytes, Smooth Muscle Myocytes, Smooth Muscle Myometrium

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